James C Bouwer
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Explore the profile of James C Bouwer including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
257
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Recent Articles
1.
McSweeney A, Eruera A, McKenzie-Goldsmith G, Bouwer J, Brown S, Stubbing L, et al.
J Virol
. 2024 Oct;
98(11):e0119324.
PMID: 39475276
Human norovirus (HuNV) is a leading cause of acute gastroenteritis worldwide with most infections caused by genogroup I and genogroup II (GII) viruses. Replication of HuNV generates both precursor and...
2.
Xu Z, Jergic S, Lo A, Pradhan A, Brown S, Bouwer J, et al.
Nat Commun
. 2024 Sep;
15(1):8372.
PMID: 39333521
Ring-shaped DNA sliding clamps are essential for DNA replication and genome maintenance. Clamps need to be opened and chaperoned onto DNA by clamp loader complexes (CLCs). Detailed understanding of the...
3.
Lau C, Flood E, Hunter M, Williams-Noonan B, Corbett K, Ng C, et al.
Nat Commun
. 2024 Aug;
15(1):7470.
PMID: 39209832
The fine tuning of biological electrical signaling is mediated by variations in the rates of opening and closing of gates that control ion flux through different ion channels. Human ether-a-go-go...
4.
Hills F, Eruera A, Hodgkinson-Bean J, Jorge F, Easingwood R, Brown S, et al.
PLoS Pathog
. 2024 May;
20(5):e1012158.
PMID: 38805567
SARS-CoV-2 is the third known coronavirus (CoV) that has crossed the animal-human barrier in the last two decades. However, little structural information exists related to the close genetic species within...
5.
Newing T, Brewster J, Fitschen L, Bouwer J, Johnston N, Yu H, et al.
Nat Commun
. 2022 Sep;
13(1):5649.
PMID: 36163171
The Redβ protein of the bacteriophage λ red recombination system is a model annealase which catalyzes single-strand annealing homologous DNA recombination. Here we present the structure of a helical oligomeric...
6.
Wang Z, Wang Y, Li B, Bouwer J, Davey K, Lu J, et al.
Angew Chem Int Ed Engl
. 2022 Aug;
61(41):e202206682.
PMID: 35982546
In traditional non-flammable electrolytes a trade-off always exists between non-flammability and battery performance. Previous research focused on reducing free solvents and forming anion-derived solid-electrolyte interphase. However, the contribution of solvated...
7.
Paudel B, Xu Z, Jergic S, Oakley A, Sharma N, Brown S, et al.
Nucleic Acids Res
. 2022 May;
50(10):5688-5712.
PMID: 35641110
Elongation by RNA polymerase is dynamically modulated by accessory factors. The transcription-repair coupling factor (TRCF) recognizes paused/stalled RNAPs and either rescues transcription or initiates transcription termination. Precisely how TRCFs choose...
8.
Gebert F, Cortie D, Bouwer J, Wang W, Yan Z, Dou S, et al.
Angew Chem Int Ed Engl
. 2021 Jun;
60(34):18519-18526.
PMID: 34096153
Manganese-based Prussian Blue, Na Mn[Fe(CN) ] (MnPB), is a good candidate for sodium-ion battery cathode materials due to its high capacity. However, it suffers from severe capacity decay during battery...
9.
Newing T, Oakley A, Miller M, Dawson C, Brown S, Bouwer J, et al.
Nat Commun
. 2020 Dec;
11(1):6420.
PMID: 33339820
In bacteria, transcription complexes stalled on DNA represent a major source of roadblocks for the DNA replication machinery that must be removed in order to prevent damaging collisions. Gram-positive bacteria...
10.
Sobti M, Ishmukhametov R, Bouwer J, Ayer A, Suarna C, Smith N, et al.
Elife
. 2019 Mar;
8.
PMID: 30912741
ATP synthase produces the majority of cellular energy in most cells. We have previously reported cryo-EM maps of autoinhibited ATP synthase imaged without addition of nucleotide (Sobti et al. 2016),...