James B Canavan
Overview
Explore the profile of James B Canavan including associated specialties, affiliations and a list of published articles.
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20
Citations
694
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Recent Articles
11.
Li K, Strauss R, Ouahed J, Chan D, Telesco S, Shouval D, et al.
J Pediatr Gastroenterol Nutr
. 2018 Feb;
67(1):45-52.
PMID: 29401083
Background: Efficacy data from adult ulcerative colitis (UC) clinical trials are often extrapolated for pediatric prescribing. Consequently, it is important to understand similarities/differences in pediatric and adult UC. Pediatric UC...
12.
Powell N, Lo J, Biancheri P, Vossenkamper A, Pantazi E, Walker A, et al.
Gastroenterology
. 2015 Apr;
149(2):456-67.e15.
PMID: 25917784
Background & Aims: Innate lymphoid cells (ILCs) are a heterogeneous group of mucosal inflammatory cells that participate in chronic intestinal inflammation. We investigated the role of interleukin 6 (IL6) in...
13.
Canavan J, Scotta C, Vossenkamper A, Goldberg R, Elder M, Shoval I, et al.
Gut
. 2015 Feb;
65(4):584-94.
PMID: 25715355
Background And Aim: Thymus-derived regulatory T cells (Tregs) mediate dominant peripheral tolerance and treat experimental colitis. Tregs can be expanded from patient blood and were safely used in recent phase...
14.
Afzali B, Mitchell P, Edozie F, Povoleri G, Dowson S, Demandt L, et al.
Eur J Immunol
. 2013 May;
43(8):2043-54.
PMID: 23677517
Treg cells are critical for the prevention of autoimmune diseases and are thus prime candidates for cell-based clinical therapy. However, human Treg cells are "plastic", and are able to produce...
15.
Afzali B, Edozie F, Fazekasova H, Scotta C, Mitchell P, Canavan J, et al.
Clin J Am Soc Nephrol
. 2013 Apr;
8(8):1396-405.
PMID: 23580782
Background And Objectives: Cell-based therapy with natural (CD4(+)CD25(hi)CD127(lo)) regulatory T cells to induce transplant tolerance is now technically feasible. However, regulatory T cells from hemodialysis patients awaiting transplantation may be...
16.
Stolarczyk E, Vong C, Perucha E, Jackson I, Cawthorne M, Wargent E, et al.
Cell Metab
. 2013 Apr;
17(4):520-33.
PMID: 23562076
Low-grade inflammation in fat is associated with insulin resistance, although the mechanisms are unclear. We report that mice deficient in the immune cell transcription factor T-bet have lower energy expenditure...
17.
Canavan J, Afzali B, Lord G, Lombardi G
Expert Rev Mol Diagn
. 2012 Dec;
13(1):5-7.
PMID: 23256698
No abstract available.
18.
Powell N, Walker A, Stolarczyk E, Canavan J, Gokmen M, Marks E, et al.
Immunity
. 2012 Oct;
37(4):674-84.
PMID: 23063332
Mice lacking the transcription factor T-bet in the innate immune system develop microbiota-dependent colitis. Here, we show that interleukin-17A (IL-17A)-producing IL-7Rα(+) innate lymphoid cells (ILCs) were potent promoters of disease...
19.
Canavan J, Afzali B, Scotta C, Fazekasova H, Edozie F, Macdonald T, et al.
Blood
. 2012 Jan;
119(8):e57-66.
PMID: 22219224
Regulatory T cells (CD4(+)CD25(hi)CD127(lo)FOXP3(+) T cells [Tregs]) are a population of lymphocytes involved in the maintenance of self-tolerance. Abnormalities in function or number of Tregs are a feature of autoimmune...
20.
Canavan J, Coss A, Leader M, Patchett S
Case Rep Gastroenterol
. 2011 Apr;
1(1):152-6.
PMID: 21487561
Mesenteric inflammatory veno-occlusive disease (MIVOD) is an uncommon but important cause of bowel inflammation. MIVOD is characterised by lymphocytic inflammation and non-thrombotic occlusion of the mesenteric venules and veins. We...