James A Votava
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Explore the profile of James A Votava including associated specialties, affiliations and a list of published articles.
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10
Citations
36
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Recent Articles
1.
Lika J, Votava J, Datta R, Kralovec A, Smith F, Huttenlocher A, et al.
bioRxiv
. 2025 Feb;
PMID: 39975244
Neutrophils are highly abundant innate immune cells that are constantly produced from myeloid progenitors in the bone marrow. Differentiated neutrophils can perform an arsenal of effector functions critical for host...
2.
Wagner A, Smith F, Bennin D, Votava J, Datta R, Giese M, et al.
PLoS Pathog
. 2025 Feb;
21(2):e1012654.
PMID: 39899622
Neutrophils are critical for host defense against fungi. However, the short life span and lack of genetic tractability of primary human neutrophils has limited in vitro analysis of neutrophil-fungal interactions....
3.
Votava J, Fan J, Parks B
PLoS One
. 2024 Dec;
19(12):e0315719.
PMID: 39666708
The lactating mammary gland strongly induces de novo lipogenesis (DNL) to support the synthesis of fatty acids, triglycerides, and cholesterol found within milk. In monogastric species, glucose is a major...
4.
Wagner A, Smith F, Bennin D, Votava J, Datta R, Giese M, et al.
bioRxiv
. 2024 Oct;
PMID: 39416161
Neutrophils are critical for host defense against fungi. However, the short life span and lack of genetic tractability of primary human neutrophils has limited analysis of neutrophil-fungal interactions. Human induced...
5.
Britt E, Qing X, Votava J, Lika J, Wagner A, Shen S, et al.
Proc Natl Acad Sci U S A
. 2024 Sep;
121(39):e2321212121.
PMID: 39284072
Neutrophils utilize a variety of metabolic sources to support their crucial functions as the first responders in innate immunity. Here, through in vivo and ex vivo isotopic tracing, we examined...
6.
Votava J, John S, Li Z, Chen S, Fan J, Parks B
J Lipid Res
. 2024 Feb;
65(3):100525.
PMID: 38417553
The availability of genome-wide transcriptomic and proteomic datasets is ever-increasing and often not used beyond initial publication. Here, we applied module-based coexpression network analysis to a comprehensive catalog of 35 ...
7.
John S, Seim G, Erazo-Flores B, Steill J, Freeman J, Votava J, et al.
bioRxiv
. 2024 Jan;
PMID: 38234794
During an immune response, macrophages systematically rewire their metabolism in specific ways to support their diversve functions. However, current knowledge of macrophage metabolism is largely concentrated on central carbon metabolism....
8.
Arp N, Seim G, Votava J, Josephson J, Fan J
J Biol Chem
. 2023 Oct;
299(11):105333.
PMID: 37827290
Branched chain α-ketoacid dehydrogenase complex (BCKDC) is the rate-limiting enzyme in branched chain amino acid (BCAA) catabolism, a metabolic pathway with great importance for human health. BCKDC belongs to the...
9.
Britt E, Qing X, Votava J, Lika J, Wagner A, Shen S, et al.
bioRxiv
. 2023 Oct;
PMID: 37808750
Neutrophils - the first responders in innate immunity - perform a variety of effector functions associated with specific metabolic demand. To maintain fitness and support functions, neutrophils have been found...
10.
Votava J, Reese S, Deck K, Nizzi C, Anderson S, Djamali A, et al.
Am J Physiol Renal Physiol
. 2021 Nov;
322(1):F89-F103.
PMID: 34843656
Chronic kidney disease involves disturbances in iron metabolism including anemia caused by insufficient erythropoietin (EPO) production. However, underlying mechanisms responsible for the dysregulation of cellular iron metabolism are incompletely defined....