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James A Fletcher

Explore the profile of James A Fletcher including associated specialties, affiliations and a list of published articles. Areas
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Recent Articles
1.
Shanmugasundaram K, Ahmed E, Miao X, Kulasinghe A, Fletcher J, Monkman J, et al.
ACS Sens . 2024 Jun; 9(6):3009-3016. PMID: 38836608
Immune checkpoint inhibitors (ICIs) targeting programmed cell death ligand 1 (PD-L1), or its receptor, PD-1 have improved survival in patients with non-small-cell lung cancer (NSCLC). Assessment of PD-L1 expression requires...
2.
Fletcher J, Mullally W, Ladwa R, OByrne K
JTO Clin Res Rep . 2024 Feb; 5(2):100591. PMID: 38357093
gene rearrangements are detected in approximately 3% to 5% of NSCLC. tyrosine kinase inhibitors, such as third-generation lorlatinib, have exhibited remarkable efficacy in -rearranged NSCLC; however, they have been associated...
3.
Fletcher J, Logan B, Reid N, Gordon E, Ladwa R, Hubbard R
BMC Cancer . 2023 Jun; 23(1):498. PMID: 37268891
Aims: The frailty index (FI) is one way in which frailty can be quantified. While it is measured as a continuous variable, various cut-off points have been used to categorise...
4.
Fletcher J, Fox S, Reid N, Hubbard R, Ladwa R
Cancer Treat Res Commun . 2022 Oct; 33:100652. PMID: 36306604
Background: Frailty is prevalent in older adults with lung cancer, however the impact of frailty in this population is not well understood. The aim of this review was to evaluate...