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Jakub Sedzinski

Explore the profile of Jakub Sedzinski including associated specialties, affiliations and a list of published articles. Areas
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Articles 10
Citations 300
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Recent Articles
1.
Tiemann U, Tian C, Hermann F, Proks M, Skovgaard E, Kulik I, et al.
Dev Cell . 2025 Mar; PMID: 40056911
A central question in cell and developmental biology is how extracellular cues control the differentiation of multipotent progenitors in a dynamically changing niche. Here, we identify apical-basal polarity as the...
2.
Lee J, Moller A, Chae S, Bussek A, Park T, Kim Y, et al.
Sci Adv . 2023 Apr; 9(14):eadd5745. PMID: 37027470
The specialized cell types of the mucociliary epithelium (MCE) lining the respiratory tract enable continuous airway clearing, with its defects leading to chronic respiratory diseases. The molecular mechanisms driving cell...
3.
Ventura G, Amiri A, Thiagarajan R, Tolonen M, Doostmohammadi A, Sedzinski J
Nat Commun . 2022 Oct; 13(1):6423. PMID: 36307428
During embryonic development, regeneration, and homeostasis, cells have to migrate and physically integrate into the target tissues where they ultimately execute their function. While much is known about the biochemical...
4.
Ventura G, Sedzinski J
Front Cell Dev Biol . 2022 Oct; 10:961460. PMID: 36238689
During embryogenesis, tissues develop into elaborate collectives through a myriad of active mechanisms, with cell migration being one of the most common. As cells migrate, they squeeze through crowded microenvironments...
5.
Tu F, Sedzinski J, Ma Y, Marcotte E, Wallingford J
J Cell Sci . 2017 Nov; 131(3). PMID: 29180514
Multiciliated cells (MCCs) drive fluid flow in diverse tubular organs and are essential for the development and homeostasis of the vertebrate central nervous system, airway and reproductive tracts. These cells...
6.
Sedzinski J, Hannezo E, Tu F, Biro M, Wallingford J
J Cell Sci . 2017 Mar; 130(5):1017. PMID: 28250089
No abstract available.
7.
Sedzinski J, Hannezo E, Tu F, Biro M, Wallingford J
J Cell Sci . 2017 Jan; 130(2):420-428. PMID: 28089989
Homeostatic replacement of epithelial cells from basal precursors is a multistep process involving progenitor cell specification, radial intercalation and, finally, apical surface emergence. Recent data demonstrate that actin-based pushing under...
8.
Sedzinski J, Hannezo E, Tu F, Biro M, Wallingford J
Dev Cell . 2016 Jan; 36(1):24-35. PMID: 26766441
Epithelial sheets are crucial components of all metazoan animals, enclosing organs and protecting the animal from its environment. Epithelial homeostasis poses unique challenges, as addition of new cells and loss...
9.
Turk E, Wills A, Kwon T, Sedzinski J, Wallingford J, Stearns T
Curr Biol . 2015 Aug; 25(16):2177-83. PMID: 26234217
There are six members of the tubulin superfamily in eukaryotes. Alpha- and beta-tubulin form a heterodimer that polymerizes to form microtubules, and gamma-tubulin nucleates microtubules as a component of the...
10.
Sedzinski J, Wallingford J
Dev Cell . 2015 Jun; 33(5):494-5. PMID: 26058051
Asymmetric localization of planar cell polarity (PCP) proteins is essential for tissue integrity, but how asymmetric localization is regulated during cell division is not known. In this issue of Developmental...