Jaime Grutzendler
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Explore the profile of Jaime Grutzendler including associated specialties, affiliations and a list of published articles.
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58
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6513
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Recent Articles
1.
Cai Y, Kanyo J, Wilson R, Bathla S, Cardozo P, Tong L, et al.
Nat Aging
. 2025 Mar;
PMID: 40065072
Dystrophic neurites (also termed axonal spheroids) are found around amyloid deposits in Alzheimer's disease (AD), where they impair axonal electrical conduction, disrupt neural circuits and correlate with AD severity. Despite...
2.
Heneka M, van der Flier W, Jessen F, Hoozemanns J, Thal D, Boche D, et al.
Nat Rev Immunol
. 2024 Dec;
PMID: 39653749
Increasing evidence points to a pivotal role of immune processes in the pathogenesis of Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing disease of our time. Multiple lines...
3.
Min W, Qin L, Zhang H, Lopez-Giraldez F, Jiang N, Kim Y, et al.
Circ Res
. 2024 Jul;
135(4):e94-e113.
PMID: 38957991
Background: Cerebral vascular malformations (CCMs) are primarily found within the brain, where they result in increased risk for stroke, seizures, and focal neurological deficits. The unique feature of the brain...
4.
Tong L, Han S, Xue Y, Chen M, Chen F, Ke W, et al.
iScience
. 2023 Sep;
26(10):107857.
PMID: 37752954
Optogenetic manipulation with single-cell resolution can be achieved by two-photon excitation. However, this frequently requires relatively high laser powers. Here, we developed a novel strategy that can improve the efficiency...
5.
Damisah E, Rai A, Hill R, Tong L, Grutzendler J
bioRxiv
. 2023 Mar;
PMID: 36993245
TREM2 and APOE are two major risk factors for Alzheimer's disease (AD) that have been proposed to play crucial roles in microglia pathophysiology by affecting their ability to phagocytose cellular...
6.
Yuan P, Zhang M, Tong L, Morse T, McDougal R, Ding H, et al.
Nature
. 2022 Nov;
612(7939):328-337.
PMID: 36450991
The precise mechanisms that lead to cognitive decline in Alzheimer's disease are unknown. Here we identify amyloid-plaque-associated axonal spheroids as prominent contributors to neural network dysfunction. Using intravital calcium and...
7.
Aber E, Griffey C, Davies T, Li A, Yang Y, Croce K, et al.
Cell Rep
. 2022 Oct;
41(3):111480.
PMID: 36261002
Although macroautophagy deficits are implicated across adult-onset neurodegenerative diseases, we understand little about how the discrete, highly evolved cell types of the central nervous system use macroautophagy to maintain homeostasis....
8.
Ando K, Tong L, Peng D, Vazquez-Liebanas E, Chiyoda H, He L, et al.
Dev Cell
. 2022 May;
57(11):1383-1399.e7.
PMID: 35588738
Loss- or gain-of-function mutations in ATP-sensitive potassium channel (K-ATP)-encoding genes, KCNJ8 and ABCC9, cause human central nervous system disorders with unknown pathogenesis. Here, using mice, zebrafish, and cell culture models,...
9.
Velasco M, Zhang M, Antonello J, Yuan P, Allgeyer E, May D, et al.
Optica
. 2021 Jul;
8(4):442-450.
PMID: 34239948
Stimulated emission depletion (STED) microscopy enables the three-dimensional (3D) visualization of dynamic nanoscale structures in living cells, offering unique insights into their organization. However, 3D-STED imaging deep inside biological tissue...
10.
Li A, Hill R, Grutzendler J
Cereb Cortex
. 2021 Apr;
31(9):4340-4356.
PMID: 33877363
Neocortical heterotopia consist of ectopic neuronal clusters that are frequently found in individuals with cognitive disability and epilepsy. However, their pathogenesis remains poorly understood due in part to a lack...