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Jagdish Chandra Joshi

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Citations 103
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Recent Articles
1.
Joshi J, Joshi B, Zhang C, Banerjee S, Vellingiri V, Raghunathrao V, et al.
iScience . 2025 Mar; 28(2):111878. PMID: 40041768
Interferon gamma (IFNγ), a type II interferon, augments tissue inflammation following infections, leading to lethal acute lung injury (ALI), yet the mechanisms controlling IFNγ generation in the lungs remain elusive....
2.
Akhter M, Yazbeck P, Tauseef M, Anwar M, Hossen F, Datta S, et al.
Cell Rep . 2024 Jun; 43(6):114297. PMID: 38824643
The mechanical environment generated through the adhesive interaction of endothelial cells (ECs) with the matrix controls nuclear tension, preventing aberrant gene synthesis and the transition from restrictive to leaky endothelium,...
3.
Vellingiri V, Balaji Ragunathrao V, Joshi J, Akhter M, Anwar M, Banerjee S, et al.
bioRxiv . 2024 May; PMID: 38746216
Highlights: ERG regulates trans-endothelial neutrophil (PMN) extravasation, retention, and activationLoss of endothelial (EC) ERG rewires PMN-transcriptomeAdopted transfer of rewired PMNs causes inflammation in a naïve mouse ERG transcribes and suppresses...
4.
Joshi J, Joshi B, Zhang C, Banerjee S, Vellingiri V, Raghunathrao V, et al.
bioRxiv . 2023 Oct; PMID: 37790514
Highlights: RGS2 levels are inversely correlated with IFNγ in ARDS patient's AM.RGS2 in alveolar macrophages regulate the inflammatory lung injury.During pathogenic insult RGS2 functioned by forming a complex with TLR4...
5.
Kleinjan M, Mao D, Naiche L, Joshi J, Gupta A, Jesse J, et al.
Arterioscler Thromb Vasc Biol . 2023 Jun; 43(8):1441-1454. PMID: 37317855
Background: Endothelial CLICs (chloride intracellular channel proteins) CLIC1 and CLIC4 are required for the GPCRs (G-protein-coupled receptors) S1PR1 (sphingosine-1-phosphate receptor 1) and S1PR3 to activate the small GTPases Rac1 (Ras-related...
6.
Rayees S, Joshi J, Joshi B, Vellingiri V, Banerjee S, Mehta D
Front Pharmacol . 2022 Oct; 13:874197. PMID: 36204227
Efficient phagocytosis of pathogens by the innate immune system during infectious injury is vital for restoring tissue integrity. Impaired phagocytosis, such as in the case of infection with , a...
7.
Joshi B, Joshi J, Mehta D
Cells . 2022 Sep; 11(18). PMID: 36139387
Cyclic GMP-AMP synthase (cGAS) is a predominant and ubiquitously expressed cytosolic onfirmedDNA sensor that activates innate immune responses by producing a second messenger, cyclic GMP-AMP (cGAMP), and the stimulator of...
8.
Rochford I, Joshi J, Rayees S, Anwar M, Akhter M, Yalagala L, et al.
Am J Physiol Lung Cell Mol Physiol . 2021 Jul; 321(4):L686-L702. PMID: 34318714
Increased lung vascular permeability and neutrophilic inflammation are hallmarks of acute lung injury. Alveolar macrophages (AMϕ), the predominant sentinel cell type in the airspace, die in massive numbers while fending...
9.
Srivastava S, Bagang N, Yadav S, Rajput S, Sharma D, Dahiya A, et al.
Inflamm Res . 2021 Jun; 70(7):743-747. PMID: 34185111
Objective: Isoproterenol (ISO) is widely used agent to study the effects of interventions which could prevent or attenuate the development of myocardial infarction. The sequence of pathological event's revealed that...
10.
Akhter M, Joshi J, Balaji Ragunathrao V, Maienschein-Cline M, Proia R, Malik A, et al.
Circ Res . 2021 Apr; 129(2):221-236. PMID: 33926208
[Figure: see text].