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Jaeline E Spowart

Explore the profile of Jaeline E Spowart including associated specialties, affiliations and a list of published articles. Areas
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Articles 4
Citations 68
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Recent Articles
1.
Townsend K, Spowart J, Huwait H, Eshragh S, West N, Elrick M, et al.
PLoS One . 2013 Dec; 8(12):e82406. PMID: 24376535
Background: When T cells infiltrate the tumor environment they encounter a myriad of metabolic stressors including hypoxia. Overcoming the limitations imposed by an inadequate tumor vasculature that contributes to these...
2.
Spowart J, Townsend K, Huwait H, Eshragh S, West N, Ries J, et al.
J Pathol . 2012 Aug; 228(4):437-47. PMID: 22926683
Clear cell ovarian cancer histotypes exhibit metabolic features associated with resistance to hypoxia and glucose deprivation-induced cell death. This metabolic characteristic suggests that clear cell ovarian cancers activate survival mechanisms...
3.
Hughson L, Poon V, Spowart J, Lum J
Int J Cell Biol . 2012 May; 2012:872091. PMID: 22550492
Accumulating evidence indicates that therapies designed to trigger apoptosis in tumor cells cause mitochondrial depolarization, nuclear damage, and the accumulation of misfolded protein aggregates, resulting in the activation of selective...
4.
Schlie K, Spowart J, Hughson L, Townsend K, Lum J
Int J Cell Biol . 2011 Dec; 2011:470597. PMID: 22190938
Hypoxia is a signature feature of growing tumors. This cellular state creates an inhospitable condition that impedes the growth and function of all cells within the immediate and surrounding tumor...