Jade Houghton
Overview
Explore the profile of Jade Houghton including associated specialties, affiliations and a list of published articles.
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7
Citations
56
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0
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Recent Articles
1.
Cable S, Baltazar M, Bunglawala F, Carmichael P, Contreas L, Dent M, et al.
Toxicol Sci
. 2024 Dec;
204(1):79-95.
PMID: 39693112
For many years, a method that allowed systemic toxicity safety assessments to be conducted without generating new animal test data, seemed out of reach. However, several different research groups and...
2.
Wood A, Breffa C, Chaine C, Cubberley R, Dent M, Eichhorn J, et al.
Toxicology
. 2024 Jun;
506:153835.
PMID: 38857863
Next Generation Risk Assessment (NGRA) is an exposure-led approach to safety assessment that uses New Approach Methodologies (NAMs). Application of NGRA has been largely restricted to assessments of consumer use...
3.
Schumann P, Rivetti C, Houghton J, Campos B, Hodges G, LaLone C
Sci Total Environ
. 2023 Nov;
912:168573.
PMID: 37981146
The ability to predict which chemicals are of concern for environmental safety is dependent, in part, on the ability to extrapolate chemical effects across many species. This work investigated the...
4.
Rivetti C, Houghton J, Basili D, Hodges G, Campos B
Environ Toxicol Chem
. 2023 Mar;
42(5):1152-1166.
PMID: 36861224
The last two decades have witnessed a strong momentum toward integration of cell-based and computational approaches in safety assessments. This is fueling a global regulatory paradigm shift toward reduction and...
5.
Middleton A, Reynolds J, Cable S, Baltazar M, Li H, Bevan S, et al.
Toxicol Sci
. 2022 Jul;
189(1):124-147.
PMID: 35822611
An important question in toxicological risk assessment is whether non-animal new approach methodologies (NAMs) can be used to make safety decisions that are protective of human health, without being overly...
6.
Basili D, Reynolds J, Houghton J, Malcomber S, Chambers B, Liddell M, et al.
Chem Res Toxicol
. 2022 Mar;
35(4):670-683.
PMID: 35333521
Estimation of points of departure (PoDs) from high-throughput transcriptomic data (HTTr) represents a key step in the development of next-generation risk assessment (NGRA). Current approaches mainly rely on single key...
7.
Baltazar M, Cable S, Carmichael P, Cubberley R, Cull T, Delagrange M, et al.
Toxicol Sci
. 2020 Apr;
176(1):236-252.
PMID: 32275751
Next-Generation Risk Assessment is defined as an exposure-led, hypothesis-driven risk assessment approach that integrates new approach methodologies (NAMs) to assure safety without the use of animal testing. These principles were...