Jacques Descotes
Overview
Explore the profile of Jacques Descotes including associated specialties, affiliations and a list of published articles.
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74
Citations
569
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Recent Articles
1.
Peloso C, Trichet A, Descotes J, Richard J, Roberge C, Lopez-Noriega A
Int J Mol Sci
. 2021 Sep;
22(17).
PMID: 34502155
The present study aims to investigate the loco-regional tolerability and injection parameters (i.e., flow rate and administration volume) of an in situ forming depot (ISFD) in Göttingen minipigs, to secure...
2.
Descotes J, Allais L, Ancian P, Pedersen H, Friry-Santini C, Iglesias A, et al.
Regul Toxicol Pharmacol
. 2018 Feb;
94:271-275.
PMID: 29481836
There is a growing need to consider non-rodent species for the immunological safety evaluation of drug candidates. The EU Framework-6 RETHINK Project demonstrated that the Göttingen Minipig is a relevant...
3.
Cottin J, Gouraud A, Jean-Pastor M, Dautriche A, Boulay C, Geniaux H, et al.
Fundam Clin Pharmacol
. 2015 Nov;
30(2):147-52.
PMID: 26588183
Etifoxine chlorhydrate is a benzoxazine derivative approved for the treatment of psychosomatic manifestations of anxiety since 1979. Previously labeled adverse drug reactions (ADRs) only include drowsiness, benign cutaneous reactions, and...
4.
Mamou Z, Descotes J, Chevalier P, Bui-Xuan B, Romestaing C, Timour Q
Fundam Clin Pharmacol
. 2015 Jun;
29(5):439-49.
PMID: 26118736
Accidental intravascular or high-dose injection of local anesthetics (LA) can result in serious, potentially life-threatening complications. Indeed, adequate supportive measures and the administration of lipid emulsions are required in such...
5.
Paret N, Dautriche A, Bera A, Gouraud A, Millaret A, Descotes J, et al.
Clin Res Hepatol Gastroenterol
. 2014 Jun;
38(4):426-31.
PMID: 24953526
Background And Objective: A decrease in factor V activity has been reported in some patients treated with azathioprine or 6-mercaptopurine. This may lead to unnecessary treatment discontinuation in otherwise asymptomatic...
6.
Leroy B, Richez A, Wolf F, Descotes J, Vial T
Therapie
. 2014 Jun;
69(2):180-1.
PMID: 24926639
Bilateral pulmonary embolism possibly related due to topically applied imiquimod is reported in a 47-year-old male patient with no evidence of risk factors.
7.
Imbert L, Boucher A, Delhome G, Cueto T, Boudinaud M, Maublanc J, et al.
J Anal Toxicol
. 2014 Jun;
38(7):410-5.
PMID: 24904014
Methoxetamine (MXE) is increasingly used and abused, as it is frequently presented as being safer than ketamine, and legal. Cases of only MXE consumption being associated with the occurrence of...
8.
Forster R, Bourtourault M, Chung Y, Silvano J, Sire G, Spezia F, et al.
Regul Toxicol Pharmacol
. 2014 May;
69(3):398-407.
PMID: 24842704
TM0601p is a whey protein isolate derived from cow milk, containing a concentrated amount of transforming growth factor β2 (TGF-β2), and is intended for nutritional use in infants and adults....
9.
Mamou Z, Chahine M, Rhondali O, Dehina L, Chevalier P, Descotes J, et al.
Fundam Clin Pharmacol
. 2014 Mar;
29(1):21-30.
PMID: 24588464
The aim of this study was to determine whether amlodipine and/or perindoprilate injected intravenously (iv) prior to ischemia exerted protective effects on mitochondria structural and functional alterations induced by ischemia...
10.
Dehina L, Descotes J, Chevalier P, Bui-Xuan B, Romestaing C, Dizerens N, et al.
Fundam Clin Pharmacol
. 2013 Apr;
28(3):257-67.
PMID: 23607936
Preventing the consequences of ischemia/reperfusion (I/R)-induced lesions in the clinic requires the administration of pharmacological agents prior to restoring coronary vascularization. The aim of this study was to evaluate the...