Jacques Behmoaras
Overview
Explore the profile of Jacques Behmoaras including associated specialties, affiliations and a list of published articles.
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Articles
56
Citations
1304
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Recent Articles
1.
Leishman S, Aljadeed N, Qian L, Cockcroft S, Behmoaras J, Anand P
Cell Rep
. 2024 Jul;
43(8):114516.
PMID: 39024103
Despite its significance, the role of lipid metabolism in NLRP3 inflammasome remains elusive. Here, we reveal a critical role for fatty acid synthase (FASN) in NLRP3 inflammasome activation. We demonstrate...
2.
Hateley C, Olona A, Halliday L, Edin M, Ko J, Forlano R, et al.
EBioMedicine
. 2024 Apr;
103:105127.
PMID: 38677183
Background: Obesity drives maladaptive changes in the white adipose tissue (WAT) which can progressively cause insulin resistance, type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated liver disease (MASLD). Obesity-mediated loss...
3.
Xie Y, Chen H, Chellamuthu V, Lajam A, Albani S, Low A, et al.
Int J Mol Sci
. 2024 Apr;
25(7).
PMID: 38612639
Single-cell RNA sequencing (scRNA-seq) has emerged as a powerful technique for investigating biological heterogeneity at the single-cell level in human systems and model organisms. Recent advances in scRNA-seq have enabled...
4.
Chen H, You R, Guo J, Zhou W, Chew G, Devapragash N, et al.
J Am Soc Nephrol
. 2024 Mar;
35(6):696-718.
PMID: 38502123
No abstract available.
5.
Ouyang J, Mishra K, Xie Y, Park H, Huang K, Petretto E, et al.
Elife
. 2023 Sep;
12.
PMID: 37706477
Tissue fibrosis affects multiple organs and involves a master-regulatory role of macrophages which respond to an initial inflammatory insult common in all forms of fibrosis. The recently unravelled multi-organ heterogeneity...
6.
Ahmadzadeh K, Pereira M, Vanoppen M, Bernaerts E, Ko J, Mitera T, et al.
EMBO Rep
. 2023 Apr;
24(4):e57070.
PMID: 37016941
No abstract available.
7.
Ahmadzadeh K, Pereira M, Vanoppen M, Bernaerts E, Ko J, Mitera T, et al.
EMBO Rep
. 2023 Jan;
24(3):e56310.
PMID: 36597777
Macrophages undergo plasma membrane fusion and cell multinucleation to form multinucleated giant cells (MGCs) such as osteoclasts in bone, Langhans giant cells (LGCs) as part of granulomas or foreign-body giant...
8.
Chen H, Chew G, Devapragash N, Loh J, Huang K, Guo J, et al.
Nat Commun
. 2022 Nov;
13(1):7375.
PMID: 36450710
Non-ischemic cardiomyopathy (NICM) can cause left ventricular dysfunction through interstitial fibrosis, which corresponds to the failure of cardiac tissue remodeling. Recent evidence implicates monocytes/macrophages in the etiopathology of cardiac fibrosis,...
9.
Muralidharan S, Torta F, Lin M, Olona A, Bagnati M, Moreno-Moral A, et al.
Front Immunol
. 2022 Jul;
13:926220.
PMID: 35844525
Toll-like receptor 4 (TLR4)-mediated changes in macrophages reshape intracellular lipid pools to coordinate an effective innate immune response. Although this has been previously well-studied in different model systems, it remains...
10.
Prendecki M, McAdoo S, Turner-Stokes T, Garcia-Diaz A, Orriss I, Woollard K, et al.
J Pathol
. 2022 Mar;
257(3):300-313.
PMID: 35239186
P2RX7, an ionotropic receptor for extracellular adenosine triphosphate (ATP), is expressed on immune cells, including macrophages, monocytes, and dendritic cells and is upregulated on nonimmune cells following injury. P2RX7 plays...