Jacqueline D Keighron
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Explore the profile of Jacqueline D Keighron including associated specialties, affiliations and a list of published articles.
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20
Citations
228
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Recent Articles
1.
Keighron J, Bonaventura J, Li Y, Yang J, DeMarco E, Hersey M, et al.
Transl Psychiatry
. 2023 Jun;
13(1):202.
PMID: 37311803
Typical and atypical dopamine uptake inhibitors (DUIs) prefer distinct conformations of the dopamine transporter (DAT) to form ligand-transporter complexes, resulting in markedly different effects on behavior, neurochemistry, and potential for...
2.
Wang Y, DeMarco E, Witzel L, Keighron J
Pharmacol Biochem Behav
. 2021 Jan;
201:173113.
PMID: 33444597
To understand the correlation between animal behaviors and the underlying neuronal circuits, it is important to monitor and record neurotransmission in the brain of freely moving animals. With the development...
3.
Mereu M, Hiranita T, Jordan C, Chun L, Lopez J, Coggiano M, et al.
Neuropsychopharmacology
. 2020 Apr;
45(9):1518-1526.
PMID: 32340023
Modafinil and methylphenidate are medications that inhibit the neuronal reuptake of dopamine, a mechanism shared with cocaine. Their use as "smart drugs" by healthy subjects poses health concerns and requires...
4.
Keighron J, Wang Y, Cans A
Annu Rev Anal Chem (Palo Alto Calif)
. 2020 Mar;
13(1):159-181.
PMID: 32151142
Neuronal transmission relies on electrical signals and the transfer of chemical signals from one neuron to another. Chemical messages are transmitted from presynaptic neurons to neighboring neurons through the triggered...
5.
Wang Y, Jonkute R, Lindmark H, Keighron J, Cans A
Langmuir
. 2019 Dec;
36(1):37-46.
PMID: 31865701
Enzymes conjugated to nanomaterials are used in the design of various biotechnologies. In the development of biosensors, surface modifications with the enzyme glucose oxidase (GOx) serve to aid the detection...
6.
Wang Y, Fathali H, Mishra D, Olsson T, Keighron J, Skibicka K, et al.
J Am Chem Soc
. 2019 Oct;
141(44):17507-17511.
PMID: 31644274
Analytical tools for quantitative measurements of glutamate, the principal excitatory neurotransmitter in the brain, are lacking. Here, we introduce a new enzyme-based amperometric sensor technique for the counting of glutamate...
7.
Newman A, Cao J, Keighron J, Jordan C, Bi G, Liang Y, et al.
Neuropsychopharmacology
. 2019 Mar;
44(8):1435-1444.
PMID: 30858517
Medication-assisted treatments are unavailable to patients with cocaine use disorders. Efforts to develop potential pharmacotherapies have led to the identification of a promising lead molecule, JJC8-091, that demonstrates a novel...
8.
Keighron J, Quarterman J, Cao J, DeMarco E, Coggiano M, Gleaves A, et al.
ACS Chem Neurosci
. 2019 Jan;
10(4):2012-2021.
PMID: 30645944
Recent discoveries have improved our understanding of the physiological and pathological roles of the dopamine transporter (DAT); however, only a few drugs are clinically available for DAT-implicated disorders. Among those...
9.
Ultrafast Glutamate Biosensor Recordings in Brain Slices Reveal Complex Single Exocytosis Transients
Wang Y, Mishra D, Bergman J, Keighron J, Skibicka K, Cans A
ACS Chem Neurosci
. 2019 Jan;
10(3):1744-1752.
PMID: 30605606
Neuronal communication relies on vesicular neurotransmitter release from signaling neurons and detection of these molecules by neighboring neurons. Glutamate, the main excitatory neurotransmitter in the mammalian brain, is involved in...
10.
Zanettini C, Scaglione A, Keighron J, Giancola J, Lin S, Newman A, et al.
Neuropharmacology
. 2018 Nov;
161:107446.
PMID: 30481526
Atypical dopamine uptake inhibitors (DUIs) bind to the dopamine transporter and inhibit the reuptake of dopamine but have lower abuse potential than psychostimulants. Several atypical DUIs can block abuse-related effects...