Jacob S Bowers
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Explore the profile of Jacob S Bowers including associated specialties, affiliations and a list of published articles.
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16
Citations
523
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Recent Articles
1.
Ware M, Phillips M, McQuinn C, Zaidi M, Knochelmann H, Greene E, et al.
JCI Insight
. 2023 Mar;
8(8).
PMID: 36881480
This study aimed to enhance antitumor immune responses to pancreatic cancer via Ab-based blockade of IL-6 and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4). Mice bearing s.c. or orthotopic pancreatic tumors were...
2.
Nelson M, Knochelmann H, Bailey S, Huff L, Bowers J, Majchrzak-Kuligowska K, et al.
Sci Adv
. 2020 Sep;
6(27).
PMID: 32937437
How naturally arising human CD4 T helper subsets affect cancer immunotherapy is unclear. We reported that human CD4CD26 T cells elicit potent immunity against solid tumors. As CD26 T cells...
3.
Knochelmann H, Dwyer C, Smith A, Bowers J, Wyatt M, Nelson M, et al.
Cancer Res
. 2020 Jun;
80(18):3920-3932.
PMID: 32561531
The accessibility of adoptive T-cell transfer therapies (ACT) is hindered by the cost and time required for product development. Here we describe a streamlined ACT protocol using Th17 cells expanded...
4.
Bowers J, Bailey S, Rubinstein M, Paulos C, Camp E
Oncol Rev
. 2019 Aug;
13(2):430.
PMID: 31456872
Pancreatic adenocarcinoma (PDAC) remains a formidable disease that needs improved therapeutic strategies. Even though immunotherapy has revolutionized treatment for various solid tumor types, it remains largely ineffective in treating individuals...
5.
Bailey S, Nelson M, Majchrzak K, Bowers J, Wyatt M, Smith A, et al.
Nat Commun
. 2017 Dec;
8(1):1961.
PMID: 29213079
CD8 T lymphocytes mediate potent immune responses against tumor, but the role of human CD4 T cell subsets in cancer immunotherapy remains ill-defined. Herein, we exhibit that CD26 identifies three...
6.
Scheffel M, Helke K, Lu P, Bowers J, Ogretmen B, Garrett-Mayer E, et al.
Sci Rep
. 2017 Nov;
7(1):15552.
PMID: 29138469
Sphingolipids regulate critical cellular processes including inflammation. Ceramide, which serves a central role in sphingolipid metabolism, is generated by six ceramide synthases (CerS) that differ in substrate specificity. CerS6 preferentially...
7.
Bowers J, Majchrzak K, Nelson M, Aksoy B, Wyatt M, Smith A, et al.
Front Immunol
. 2017 Oct;
8:1221.
PMID: 29033940
Phosphatidylinositol-3-kinase p110δ (PI3Kδ) inhibition by Idelalisib (CAL-101) in hematological malignancies directly induces apoptosis in cancer cells and disrupts immunological tolerance by depleting regulatory T cells. Yet, little is known about...
8.
Neal L, Bailey S, Wyatt M, Bowers J, Majchrzak K, Nelson M, et al.
J Immunol Res Ther
. 2017 Aug;
2(1):68-79.
PMID: 28825053
Adoptive T cell transfer (ACT) can mediate objective responses in patients with advanced malignancies. There have been major advances in this field, including the optimization of the generation of tumor-reactive...
9.
Malik B, Byrne K, Vella J, Zhang P, Shabaneh T, Steinberg S, et al.
Sci Immunol
. 2017 Jul;
2(10).
PMID: 28738020
Tissue-resident memory T (T) cells have been widely characterized in infectious disease settings; however, their role in mediating immunity to cancer remains unknown. We report that skin-resident memory T cell...
10.
Majchrzak K, Nelson M, Bowers J, Bailey S, Wyatt M, Wrangle J, et al.
JCI Insight
. 2017 Apr;
2(8).
PMID: 28422756
ICOS costimulation generates Th17 cells with durable memory responses to tumor. Herein, we found that ICOS induces PI3K/p110δ/Akt and Wnt/β-catenin pathways in Th17 cells. Coinhibiting PI3Kδ and β-catenin altered the...