Jacob Richards
Overview
Explore the profile of Jacob Richards including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
738
Followers
0
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Recent Articles
1.
Alli A, Yu L, Holzworth M, Richards J, Cheng K, Lynch I, et al.
Am J Physiol Renal Physiol
. 2019 Feb;
316(5):F807-F813.
PMID: 30759025
Circadian rhythms govern physiological functions and are important for overall health. The molecular circadian clock comprises several transcription factors that mediate circadian control of physiological function, in part, by regulating...
2.
Lepone L, Donahue R, Grenga I, Metenou S, Richards J, Heery C, et al.
J Circ Biomark
. 2017 Sep;
5:5.
PMID: 28936253
Recent advances in human immunology have led to the identification of novel immune cell subsets and the biological function of many of these subsets has now been identified. The recent...
3.
Roselli M, Formica V, Cereda V, Jochems C, Richards J, Grenga I, et al.
Oncoimmunology
. 2016 Sep;
5(7):e1188243.
PMID: 27622042
The first-line standard of care for patients with metastatic colorectal cancer (mCRC) is FOLFIRI (irinotecan, levo-leucovorin, 5-fluorouracil (5-FU)) plus bevacizumab. With the renewed interest in cancer immunotherapy with agents such...
4.
Duggan M, Jochems C, Donahue R, Richards J, Karpa V, Foust E, et al.
Cancer Immunol Immunother
. 2016 Sep;
65(11):1353-1364.
PMID: 27581603
Prime-boost vaccination with recombinant (r) vaccinia(V)-CEA(6D)-TRICOM (triad of co-stimulatory molecules B7.1, ICAM-1 and LFA-3) and rFowlpox(F)-CEA(6D)-TRICOM infect antigen-presenting cells and direct expression of co-stimulatory molecules. We hypothesized that co-administration of...
5.
Grenga I, Donahue R, Lepone L, Richards J, Schlom J
Clin Transl Immunology
. 2016 Jun;
5(5):e83.
PMID: 27350882
Monoclonal antibodies (MAbs) that interfere with checkpoint molecules are being investigated for the treatment of infectious diseases and cancer, with the aim of enhancing the function of an impaired immune...
6.
Fujii R, Friedman E, Richards J, Tsang K, Heery C, Schlom J, et al.
Oncotarget
. 2016 May;
7(23):33498-511.
PMID: 27172898
Chordoma, a rare bone tumor derived from the notochord, has been shown to be resistant to conventional therapies. Checkpoint inhibition has shown great promise in immune-mediated therapy of diverse cancers....
7.
Kwilas A, Ardiani A, Gameiro S, Richards J, Hall A, Hodge J
Oncotarget
. 2016 Mar;
7(17):23498-511.
PMID: 27015557
Among breast cancer types, triple-negative breast cancer (TNBC) has the fewest treatment options and the lowest 5-year survival rate. Androgen receptor (AR) inhibition has displayed efficacy against breast cancer preclinically...
8.
Solocinski K, Richards J, All S, Cheng K, Khundmiri S, Gumz M
Am J Physiol Renal Physiol
. 2015 Sep;
309(11):F933-42.
PMID: 26377793
We have previously demonstrated that the circadian clock protein period (Per)1 coordinately regulates multiple genes involved in Na(+) reabsorption in renal collecting duct cells. Consistent with these results, Per1 knockout...
9.
Richards J, Diaz A, Gumz M
Blood Press Monit
. 2014 Jul;
19(5):249-54.
PMID: 25025868
The circadian clock plays an integral role in the regulation of physiological processes, including the regulation of blood pressure. However, deregulation of the clock can lead to pathophysiological states including...
10.
Richards J, Welch A, Barilovits S, All S, Cheng K, Wingo C, et al.
Life Sci
. 2014 Apr;
118(2):255-62.
PMID: 24721511
Aims: The present study is designed to consider a role for the circadian clock protein Per1 in the regulation of the endothelin axis in mouse kidney, lung, liver and heart....