Jacob E Gillis
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Explore the profile of Jacob E Gillis including associated specialties, affiliations and a list of published articles.
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7
Citations
267
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Recent Articles
1.
Liu A, Zhang Y, Chen C, Edwards T, Ozyaman S, Ramcke T, et al.
Science
. 2025 Jan;
387(6733):eadn9390.
PMID: 39883751
Itch is a dominant symptom in dermatitis, and scratching promotes cutaneous inflammation, thereby worsening disease. However, the mechanisms through which scratching exacerbates inflammation and whether scratching provides benefit to the...
2.
LaFleur M, DAndrea J, Patterson D, Streeter I, Coxe M, Osborn J, et al.
J Immunol
. 2024 Oct;
213(10):1528-1541.
PMID: 39373572
CD8+ T cells differentiate into two subpopulations in response to acute viral infection: memory precursor effector cells (MPECs) and short-lived effector cells (SLECs). MPECs and SLECs are epigenetically distinct; however,...
3.
Deng L, Gillis J, Chiu I, Kaplan D
Immunity
. 2024 Apr;
57(4):815-831.
PMID: 38599172
The sensory nervous system possesses the ability to integrate exogenous threats and endogenous signals to mediate downstream effector functions. Sensory neurons have been shown to activate or suppress host defense...
4.
LaFleur M, Lemmen A, Streeter I, Nguyen T, Milling L, Derosia N, et al.
Nat Immunol
. 2023 Nov;
25(1):178-188.
PMID: 38012416
Annotation of immunologic gene function in vivo typically requires the generation of knockout mice, which is time consuming and low throughput. We previously developed CHimeric IMmune Editing (CHIME), a CRISPR-Cas9...
5.
Liu A, Gillis J, Sumpter T, Kaplan D
J Allergy Clin Immunol
. 2023 May;
151(5):1169-1177.
PMID: 37149370
The skin is a barrier organ populated by many types of skin-resident immune cells and sensory neurons. It has become increasingly appreciated that neuroimmune interactions are an important component of...
6.
Drijvers J, Gillis J, Muijlwijk T, Nguyen T, Gaudiano E, Harris I, et al.
Cancer Immunol Res
. 2020 Dec;
9(2):184-199.
PMID: 33277233
Metabolic constraints in the tumor microenvironment constitute a barrier to effective antitumor immunity and similarities in the metabolic properties of T cells and cancer cells impede the specific therapeutic targeting...
7.
LaFleur M, Nguyen T, Coxe M, Miller B, Yates K, Gillis J, et al.
Nat Immunol
. 2019 Sep;
20(10):1335-1347.
PMID: 31527834
CD8 T cell exhaustion is a state of dysfunction acquired in chronic viral infection and cancer, characterized by the formation of Slamf6 progenitor exhausted and Tim-3 terminally exhausted subpopulations through...
8.
LaFleur M, Nguyen T, Coxe M, Yates K, Trombley J, Weiss S, et al.
Nat Commun
. 2019 Apr;
10(1):1668.
PMID: 30971695
Therapies that target the function of immune cells have significant clinical efficacy in diseases such as cancer and autoimmunity. Although functional genomics has accelerated therapeutic target discovery in cancer, its...