Jaclyn M Eissman
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Explore the profile of Jaclyn M Eissman including associated specialties, affiliations and a list of published articles.
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6
Citations
57
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Recent Articles
1.
Eissman J, Qiao M, Kalia V, Zerlin-Esteves M, Reyes-Dumeyer D, Piriz A, et al.
medRxiv
. 2025 Mar;
PMID: 40061336
We investigated genetic regulators of circulating plasma metabolites to identify pathways underlying biochemical changes in clinical and biomarker-assisted diagnosis of Alzheimer's disease (AD). We computed metabolite quantitative trait loci by...
2.
Arenaza-Urquijo E, Boyle R, Casaletto K, Anstey K, Vila-Castelar C, Colverson A, et al.
Alzheimers Dement
. 2024 Jul;
20(8):5695-5719.
PMID: 38967222
Sex and gender-biological and social constructs-significantly impact the prevalence of protective and risk factors, influencing the burden of Alzheimer's disease (AD; amyloid beta and tau) and other pathologies (e.g., cerebrovascular...
3.
Archer D, Eissman J, Mukherjee S, Lee M, Choi S, Scollard P, et al.
Alzheimers Dement
. 2023 Nov;
20(2):1268-1283.
PMID: 37985223
Introduction: Although large-scale genome-wide association studies (GWAS) have been conducted on AD, few have been conducted on continuous measures of memory performance and memory decline. Methods: We conducted a cross-ancestry...
4.
Eissman J, Archer D, Mukherjee S, Lee M, Choi S, Scollard P, et al.
Alzheimers Dement
. 2023 Nov;
20(2):1250-1267.
PMID: 37984853
Background: Women demonstrate a memory advantage when cognitively healthy yet lose this advantage to men in Alzheimer's disease. However, the genetic underpinnings of this sex difference in memory performance remain...
5.
Walters S, Contreras A, Eissman J, Mukherjee S, Lee M, Choi S, et al.
JAMA Neurol
. 2023 Jul;
80(9):929-939.
PMID: 37459083
Importance: Sex differences are established in associations between apolipoprotein E (APOE) ε4 and cognitive impairment in Alzheimer disease (AD). However, it is unclear whether sex-specific cognitive consequences of APOE are...
6.
Eissman J, Wells G, Khan O, Liu D, Petyuk V, Gifford K, et al.
Pac Symp Biocomput
. 2022 Dec;
28:449-460.
PMID: 36540999
Late-onset Alzheimer's disease (LOAD) is a polygenic disorder with a long prodromal phase, making early diagnosis challenging. Twin studies estimate LOAD as 60-80% heritable, and while common genetic variants can...
7.
Eissman J, Dumitrescu L, Mahoney E, Smith A, Mukherjee S, Lee M, et al.
Brain
. 2022 May;
145(7):2541-2554.
PMID: 35552371
Approximately 30% of elderly adults are cognitively unimpaired at time of death despite the presence of Alzheimer's disease neuropathology at autopsy. Studying individuals who are resilient to the cognitive consequences...