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Jack W OSullivan

Explore the profile of Jack W OSullivan including associated specialties, affiliations and a list of published articles. Areas
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Articles 31
Citations 853
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Recent Articles
1.
Kim D, Schuetz N, Johnson A, Tolas A, Mantena S, OSullivan J, et al.
Prog Cardiovasc Dis . 2025 Jan; PMID: 39884325
Background: The six-minute walk test (6MWT) is a prognostic sub-maximal exercise test used clinically as a measure of functional capacity. With the emergence of advanced sensors, 6MWTs are being performed...
2.
Kim D, Chu E, Keamy-Minor E, Paranjpe I, Tang W, OSullivan J, et al.
Front Cardiovasc Med . 2024 Sep; 11:1429230. PMID: 39314763
Mavacamten is a first-in-class cardiac myosin ATPase inhibitor, approved by the United States Food and Drug Administration for the treatment of hypertrophic cardiomyopathy with obstructive physiology (oHCM). Here, we present...
3.
Gomes B, Singh A, OSullivan J, Schnurr T, Goddard P, Loong S, et al.
Nat Genet . 2023 Dec; 56(2):245-257. PMID: 38082205
Cardiac blood flow is a critical determinant of human health. However, the definition of its genetic architecture is limited by the technical challenge of capturing dynamic flow volumes from cardiac...
4.
Javed A, Kim D, Hershman S, Shcherbina A, Johnson A, Tolas A, et al.
Eur Heart J Digit Health . 2023 Oct; 4(5):411-419. PMID: 37794870
Aims: Physical activity is associated with decreased incidence of the chronic diseases associated with aging. We previously demonstrated that digital interventions delivered through a smartphone app can increase short-term physical...
5.
OSullivan J, Ashley E, Elliott P
Eur Heart J . 2022 Dec; 44(2):89-99. PMID: 36478054
Cardiometabolic diseases contribute more to global morbidity and mortality than any other group of disorders. Polygenic risk scores (PRSs), the weighted summation of individually small-effect genetic variants, represent an advance...
6.
OSullivan J, Raghavan S, Marquez-Luna C, Luzum J, Damrauer S, Ashley E, et al.
Circulation . 2022 Jul; 146(8):e93-e118. PMID: 35862132
Cardiovascular disease is the leading contributor to years lost due to disability or premature death among adults. Current efforts focus on risk prediction and risk factor mitigation' which have been...
7.
Schnurr T, Katz S, Justesen J, OSullivan J, Saliba-Gustafsson P, Assimes T, et al.
Hepatol Commun . 2022 Mar; 6(7):1516-1526. PMID: 35293152
Genetic predisposition and unhealthy lifestyle are risk factors for nonalcoholic fatty liver disease (NAFLD). We investigated whether the genetic risk of NAFLD is modified by physical activity, muscular fitness, and/or...
8.
Ho V, OSullivan J, Collins W, Ozdalga E, Bell C, Shah N, et al.
JACC Case Rep . 2022 Mar; 4(5):271-275. PMID: 35257101
We present a case of pericardial amyloidosis with associated lymphoplasmacytic lymphoma in a patient with chronic worsening shortness of breath and cough. This case highlights the wide variation in the...
9.
OSullivan J, Ioannidis J
Sci Rep . 2021 Sep; 11(1):18625. PMID: 34545148
With the establishment of large biobanks, discovery of single nucleotide variants (SNVs, also known as single nucleotide polymorphisms (SNVs)) associated with various phenotypes has accelerated. An open question is whether...
10.
OSullivan J, Shcherbina A, Justesen J, Turakhia M, Perez M, Wand H, et al.
Circ Genom Precis Med . 2021 May; 14(3):e003168. PMID: 34029116
Background: Atrial fibrillation (AF) is associated with a five-fold increased risk of ischemic stroke. A portion of this risk is heritable; however, current risk stratification tools (CHADS-VASc) do not include...