Jack Sharkey
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Explore the profile of Jack Sharkey including associated specialties, affiliations and a list of published articles.
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Citations
223
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Recent Articles
1.
Muniz-Garcia A, Pichardo A, Littlewood J, Tasker S, Sharkey J, Wilm B, et al.
Nanoscale Adv
. 2023 Oct;
5(20):5520-5528.
PMID: 37822909
Tracking the biodistribution of cell therapies is crucial for understanding their safety and efficacy. Optical imaging techniques are particularly useful for tracking cells due to their clinical translatability and potential...
2.
Bhaduri S, Kelly C, Lesbats C, Sharkey J, Ressel L, Mukherjee S, et al.
NMR Biomed
. 2022 Oct;
36(3):e4855.
PMID: 36269130
Changes in glioblastoma (GBM) metabolism was investigated in response to JAS239, a choline kinase inhibitor, using MRS. In addition to the inhibition of phosphocholine synthesis, we investigated changes in other...
3.
Ashraf S, Taylor A, Sharkey J, Barrow M, Murray P, Wilm B, et al.
Nanoscale Adv
. 2022 Sep;
1(1):367-377.
PMID: 36132463
Nanoparticle contrast agents are useful tools to label stem cells and monitor the bio-distribution of labeled cells in pre-clinical models of disease. In this context, understanding the fate of the...
4.
Soliman M, Davies H, Sharkey J, Levy R, Madine J
PLoS One
. 2022 Mar;
17(3):e0259608.
PMID: 35333865
Propagation of small amyloid beta (Aβ) aggregates (or seeds) has been suggested as a potential mechanism of Alzheimer's disease progression. Monitoring the propagation of Aβ seeds in an organism would...
5.
Bhaduri S, Lesbats C, Sharkey J, Kelly C, Mukherjee S, Taylor A, et al.
Cancers (Basel)
. 2022 Mar;
14(5).
PMID: 35267531
To investigate the utility of DCE-MRI derived pharmacokinetic parameters in evaluating tumour haemodynamic heterogeneity and treatment response in rodent models of glioblastoma, imaging was performed on intracranial F98 and GL261...
6.
Harwood R, Bridge J, Ressel L, Scarfe L, Sharkey J, Czanner G, et al.
Physiol Rep
. 2022 Mar;
10(5):e15211.
PMID: 35266337
Background: Renal ischemia reperfusion injury (R-IRI) can cause acute kidney injury (AKI) and chronic kidney disease (CKD), resulting in significant morbidity and mortality. To understand the underlying mechanisms, reproducible small-animal...
7.
Yang Y, Fryer C, Sharkey J, Thomas A, Wais U, Jackson A, et al.
ACS Appl Mater Interfaces
. 2020 May;
12(25):27930-27939.
PMID: 32463217
Noninvasive bioimaging techniques are critical for assessing the biodistribution of cellular therapies longitudinally. Among them, photoacoustic imaging (PAI) can generate high-resolution images with a tissue penetration depth of ∼4 cm....
8.
Taylor A, Sharkey J, Harwood R, Scarfe L, Barrow M, Rosseinsky M, et al.
Mol Imaging Biol
. 2019 Dec;
22(4):904-913.
PMID: 31823201
Purpose: The question of whether mesenchymal stromal cells (MSCs) home to injured kidneys remains a contested issue. To try and understand the basis for contradictory findings reported in the literature,...
9.
Minhas A, Sharkey J, Randtke E, Murray P, Wilm B, Pagel M, et al.
Mol Imaging Biol
. 2019 Sep;
22(3):494-503.
PMID: 31529408
To establish multi-modal imaging for the assessment of kidney pH, perfusion, and clearance rate using magnetic resonance imaging (MRI) and multispectral optoacoustic tomography (MSOT) in healthy mice. Kidney pH and...
10.
Sharkey J, Ressel L, Brillant N, Scarfe L, Wilm B, Park B, et al.
Stem Cells Int
. 2019 May;
2019:7386954.
PMID: 31065278
Cell-based regenerative medicine therapies require robust preclinical safety, efficacy, biodistribution, and engraftment data prior to clinical testing. To address these challenges, we have developed an imaging toolbox comprising multispectral optoacoustic...