Jack J Haitsma
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Explore the profile of Jack J Haitsma including associated specialties, affiliations and a list of published articles.
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54
Citations
1171
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Recent Articles
1.
Shan Y, Akram A, Amatullah H, Zhou D, Gali P, Maron-Gutierrez T, et al.
Antioxid Redox Signal
. 2014 Nov;
22(8):651-68.
PMID: 25401197
Aims: Ventilator-induced lung injury (VILI) contributes to mortality in patients with acute respiratory distress syndrome, the most severe form of acute lung injury (ALI). Absence of activating transcription factor 3...
2.
Kuiper J, Groeneveld A, Haitsma J, Smeding L, Begieneman M, Jothy S, et al.
BMC Nephrol
. 2014 Jul;
15:126.
PMID: 25073618
Background: Intratracheal aspiration and sepsis are leading causes of acute lung injury that frequently necessitate mechanical ventilation (MV), which may aggravate lung injury thereby potentially increasing the risk of acute...
3.
Mirabella L, Grasselli G, Haitsma J, Zhang H, Slutsky A, Sinderby C, et al.
Crit Care
. 2014 Jan;
18(1):R22.
PMID: 24456613
Introduction: Experimental work provides insight into potential lung protective strategies. The objective of this study was to evaluate markers of ventilator-induced lung injury after two different ventilation approaches: (1) a...
4.
Santos C, Murthy S, Hu P, Shan Y, Haitsma J, Mei S, et al.
Am J Pathol
. 2012 Oct;
181(5):1681-92.
PMID: 23083833
Although bone marrow-derived mesenchymal stem cell (MSC) systemic administration reduces sepsis-associated inflammation, organ injury, and mortality in clinically relevant models of polymicrobial sepsis, the cellular and molecular mechanisms mediating beneficial...
5.
Hu P, Wang X, Haitsma J, Furmli S, Masoom H, Liu M, et al.
PLoS One
. 2012 Oct;
7(10):e45506.
PMID: 23071521
Objectives: To perform a meta-analysis of gene expression microarray data from animal studies of lung injury, and to identify an injury-specific gene expression signature capable of predicting the development of...
6.
Fortis S, Spieth P, Lu W, Parotto M, Haitsma J, Slutsky A, et al.
Intensive Care Med
. 2012 Jun;
38(9):1548-55.
PMID: 22711173
Purpose: Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter through activation of GABA receptors. Volatile anesthetics activate type-A (GABA(A)) receptors resulting in inhibition of synaptic transmission. Lung epithelial cells have...
7.
Smeding L, Leong-Poi H, Hu P, Shan Y, Haitsma J, Horvath E, et al.
Crit Care Med
. 2012 May;
40(6):1896-907.
PMID: 22610192
Objectives: We hypothesized that resveratrol administration would reverse sepsis-dependent downregulation of peroxisome proliferator activated receptor-γ coactivator 1α, preserve mitochondrial integrity, and rescue animals from sepsis-induced myocardial failure. Setting: Teaching hospital...
8.
Kuiper J, Plotz F, Groeneveld A, Haitsma J, Jothy S, Vaschetto R, et al.
BMC Anesthesiol
. 2011 Dec;
11:26.
PMID: 22204611
Background: To examine whether acute lung injury from direct and indirect origins differ in susceptibility to ventilator-induced lung injury (VILI) and resultant systemic inflammatory responses. Methods: Rats were challenged by...
9.
Haitsma J
Curr Opin Anaesthesiol
. 2011 Feb;
24(2):214-8.
PMID: 21293265
Purpose Of Review: It has become clear from experimental data that prolonged mechanical ventilation can induce diaphragm dysfunction, also known as ventilator-induced diaphragm dysfunction. In this article we will discuss...
10.
Han B, Haitsma J, Zhang Y, Bai X, Rubacha M, Keshavjee S, et al.
Intensive Care Med
. 2010 Nov;
37(2):334-42.
PMID: 21072499
Objective: Long pentraxin PTX3 is an inflammatory mediator and a component of the humoral arm of innate immunity. PTX3 expression is increased in animals with acute lung injury (ALI) and...