Jack Humphrey
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Explore the profile of Jack Humphrey including associated specialties, affiliations and a list of published articles.
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44
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2536
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Recent Articles
1.
Humphrey J, Brophy E, Kosoy R, Zeng B, Coccia E, Mattei D, et al.
Nat Genet
. 2025 Mar;
57(3):604-615.
PMID: 40033057
Microglia, the innate immune cells of the central nervous system, have been genetically implicated in multiple neurodegenerative diseases. Mapping the genetics of gene expression in human microglia has identified several...
2.
Rambarack N, Fodder K, Murthy M, Toomey C, de Silva R, Heutink P, et al.
bioRxiv
. 2025 Feb;
PMID: 39975316
Frontotemporal Lobar Degeneration (FTLD) represents a spectrum of clinically, genetically, and pathologically heterogeneous neurodegenerative disorders characterised by progressive atrophy of the frontal and temporal lobes of the brain. The two...
3.
Farrell K, Humphrey J, Chang T, Zhao Y, Leung Y, Kuksa P, et al.
Nat Commun
. 2024 Nov;
15(1):9828.
PMID: 39537593
No abstract available.
4.
Farrell K, Humphrey J, Chang T, Zhao Y, Leung Y, Kuksa P, et al.
Nat Commun
. 2024 Sep;
15(1):7880.
PMID: 39251599
Progressive supranuclear palsy (PSP), a rare Parkinsonian disorder, is characterized by problems with movement, balance, and cognition. PSP differs from Alzheimer's disease (AD) and other diseases, displaying abnormal microtubule-associated protein...
5.
Ressler H, Humphrey J, Vialle R, Babrowicz B, Kandoi S, Raj T, et al.
Acta Neuropathol Commun
. 2024 Aug;
12(1):135.
PMID: 39154163
Progressive supranuclear palsy (PSP) is a neurodegenerative movement and cognitive disorder characterized by abnormal accumulation of the microtubule-associated protein tau in the brain. Biochemically, inclusions in PSP are enriched for...
6.
Pasquini L, Pereira F, Seddighi S, Zeng Y, Wei Y, Illan-Gala I, et al.
Brain
. 2024 Jun;
147(9):3032-3047.
PMID: 38940350
In frontotemporal lobar degeneration (FTLD), pathological protein aggregation in specific brain regions is associated with declines in human-specialized social-emotional and language functions. In most patients, disease protein aggregates contain either...
7.
Brown A, Wilkins O, Keuss M, Hill S, Zanovello M, Lee W, et al.
Nature
. 2024 Jun;
631(8020):E7.
PMID: 38890465
No abstract available.
8.
Navarro E, Efthymiou A, Parks M, Riboldi G, Vialle R, Udine E, et al.
bioRxiv
. 2024 Jun;
PMID: 38854101
The G2019S mutation in the leucine-rich repeat kinase 2 (LRRK2) gene is a major risk factor for the development of Parkinson's disease (PD). LRRK2, although ubiquitously expressed, is highly abundant...
9.
Kopell B, Kaji D, Liharska L, Vornholt E, Valentine A, Lund A, et al.
medRxiv
. 2024 May;
PMID: 38798344
The prefrontal cortex (PFC) is a region of the brain that in humans is involved in the production of higher-order functions such as cognition, emotion, perception, and behavior. Neurotransmission in...
10.
Koromina M, Ravi A, Panagiotaropoulou G, Schilder B, Humphrey J, Braun A, et al.
medRxiv
. 2024 Feb;
PMID: 38405768
Bipolar disorder (BD) is a heritable mental illness with complex etiology. While the largest published genome-wide association study identified 64 BD risk loci, the causal SNPs and genes within these...