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Jack Feltham

Explore the profile of Jack Feltham including associated specialties, affiliations and a list of published articles. Areas
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Articles 4
Citations 191
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Recent Articles
1.
Zhang H, Alsaleh G, Feltham J, Sun Y, Napolitano G, Riffelmacher T, et al.
Mol Cell . 2019 Sep; 76(1):110-125.e9. PMID: 31474573
Failure to make adaptive immune responses is a hallmark of aging. Reduced B cell function leads to poor vaccination efficacy and a high prevalence of infections in the elderly. Here...
2.
Bilsland E, van Vliet L, Williams K, Feltham J, Carrasco M, Fotoran W, et al.
Sci Rep . 2018 Jan; 8(1):1038. PMID: 29348637
Malaria, caused by parasites of the genus Plasmodium, leads to over half a million deaths per year, 90% of which are caused by Plasmodium falciparum. P. vivax usually causes milder...
3.
Llorian M, Gooding C, Bellora N, Hallegger M, Buckroyd A, Wang X, et al.
Nucleic Acids Res . 2016 Jun; 44(18):8933-8950. PMID: 27317697
Alternative splicing (AS) is a key component of gene expression programs that drive cellular differentiation. Smooth muscle cells (SMCs) are important in the function of a number of physiological systems;...
4.
Lambert L, Walker S, Feltham J, Lee H, Reik W, Houseley J
PLoS One . 2013 Dec; 8(12):e82110. PMID: 24324754
During B cell activation, the DNA lesions that initiate somatic hypermutation and class switch recombination are introduced by activation-induced cytidine deaminase (AID). AID is a highly mutagenic protein that is...