J Y Niederkorn
Overview
Explore the profile of J Y Niederkorn including associated specialties, affiliations and a list of published articles.
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165
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2411
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Recent Articles
1.
Paunicka K, Mellon J, Robertson D, Petroll M, Brown J, Niederkorn J
Am J Transplant
. 2015 Apr;
15(6):1490-501.
PMID: 25872977
Less than 10% of corneal allografts undergo rejection even though HLA matching is not performed. However, second corneal transplants experience a threefold increase in rejection, which is not due to...
2.
3.
Cunnusamy K, Niederkorn J
Am J Transplant
. 2013 Oct;
13(12):3076-84.
PMID: 24119152
Th1 CD4+ cells are believed to be the primary mediators of corneal allograft rejection. However, rejection of fully allogeneic C57BL/6 corneal allografts soared from 50% to 90% in both interferon-gamma...
4.
Zhang X, Schaumburg C, Coursey T, Siemasko K, Volpe E, Gandhi N, et al.
Mucosal Immunol
. 2013 Sep;
7(2):417-27.
PMID: 24022789
This study investigated the regulatory function of CD8⁺ cells in T helper-17 (Th17) cell-mediated corneal epithelial barrier disruption that develops in a murine desiccating stress (DS) model that resembles Sjögren...
5.
Reyes N, Chen P, Niederkorn J
Am J Transplant
. 2013 Mar;
13(5):1181-92.
PMID: 23489547
Allergic diseases rob corneal allografts of immune privilege and increase immune rejection. Corneal allograft rejection in BALB/c allergic hosts was analyzed using a short ragweed (SWR) pollen model of allergic...
6.
Stern M, Schaumburg C, Dana R, Calonge M, Niederkorn J, Pflugfelder S
Mucosal Immunol
. 2010 May;
3(5):425-42.
PMID: 20485329
A healthy ocular surface environment is essential to preserve visual function, and as such the eye has evolved a complex network of mechanisms to maintain homeostasis. Fundamental to the health...
7.
Niederkorn J, Chen P, Mellon J, Stevens C, Mayhew E
Am J Transplant
. 2009 May;
9(5):1017-26.
PMID: 19422331
Corneal allografts transplanted into hosts with allergic conjunctivitis experience an increased incidence and swifter tempo of immune rejection compared to corneal allografts transplanted to nonallergic hosts. Previous findings suggested that...
8.
de Paiva C, Chotikavanich S, Pangelinan S, Pitcher 3rd J, Fang B, Zheng X, et al.
Mucosal Immunol
. 2009 Feb;
2(3):243-53.
PMID: 19242409
T helper (Th)-17 is a recently identified subtype of Th response that has been implicated in host defense and autoimmunity. We investigated whether there is evidence for a Th-17 response...
9.
Garate M, Alizadeh H, Neelam S, Niederkorn J, Panjwani N
Infect Immun
. 2006 Sep;
74(12):7032-4.
PMID: 16982837
Acanthamoeba castellanii mannose-binding protein (MBP) mediates adhesion of the amoebae to corneal epithelial cells, a key first step in the pathogenesis of Acanthamoeba keratitis (AK), a devastating corneal infection. In...
10.
Niederkorn J, Stevens C, Mellon J, Mayhew E
Am J Transplant
. 2006 Mar;
6(4):705-13.
PMID: 16539627
We examined the role of perforin and FasL in corneal allograft rejection mediated by CD8+ and CD8 T cells. BALB/c corneas were transplanted orthotopically into vascularized, 'high-risk' graft beds in...