J W van der Laan
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Explore the profile of J W van der Laan including associated specialties, affiliations and a list of published articles.
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50
Citations
386
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Recent Articles
1.
Heldring M, Duijndam B, Kyriakidou A, van der Meer O, Tedeschi M, van der Laan J, et al.
Heliyon
. 2024 Nov;
10(21):e38406.
PMID: 39583845
Various groups of chemicals that we encounter in every-day life are known to disrupt the endocrine system, such as estrogen mimics that can disturb normal cellular development and homeostasis. To...
2.
Schilder N, Tiesjema B, Theunissen P, Rengerink K, van der Laan J
Regul Toxicol Pharmacol
. 2023 Jun;
142:105438.
PMID: 37356612
In this study we evaluated the outcomes of non-clinical toxicity studies of various SARS-CoV-2 vaccines produced with different manufacturing technologies, with focus on Repeated Dose Toxicity (RDT) and Developmental and...
3.
Sato Y, Bando H, Di Piazza M, Gowing G, Herberts C, Jackman S, et al.
Cytotherapy
. 2019 Nov;
21(11):1095-1111.
PMID: 31711733
Pluripotent stem cells offer the potential for an unlimited source for cell therapy products. However, there is concern regarding the tumorigenicity of these products in humans, mainly due to the...
4.
Ghalandari N, Dolhain R, Hazes J, Siezen C, van der Laan J, Crijns H, et al.
Br J Clin Pharmacol
. 2019 Oct;
86(3):580-590.
PMID: 31633830
Aims: The effects of biologics on reproduction/lactation are mostly unknown although many patients that receive biologics are women of reproductive age. The first objective of this study was to investigate...
5.
Theunissen P, Beken S, Cappon G, Chen C, Hoberman A, van der Laan J, et al.
Reprod Toxicol
. 2014 Dec;
47:27-32.
PMID: 25517003
Based on a proposal made at the ICH Workshop in Tallinn, Estonia (2010), the value of the rabbit embryo-fetal development (EFD) versus the rodent EFD was examined by the HESI...
6.
ter Braak B, Siezen C, Kannegieter N, Koedoot E, van de Water B, van der Laan J
Arch Toxicol
. 2014 Jan;
88(4):953-66.
PMID: 24464500
Insulin analogues are widely used in clinical practice. Modifications on the insulin molecular structure can affect the affinity and activation towards two closely related receptor tyrosine kinases: the insulin receptor...
7.
van Meer P, Kooijman M, van der Laan J, Moors E, Schellekens H
Nat Biotechnol
. 2013 Oct;
31(10):882-3.
PMID: 24104750
No abstract available.
8.
de Jong H, Klungel O, van Dijk L, Vandebriel R, Leufkens H, van der Laan J, et al.
Ann Rheum Dis
. 2011 Oct;
71(5):648-54.
PMID: 21979000
Objectives: Statins offer significant cardiovascular benefits. Their use, however, influences immune regulation, which may potentially facilitate autoimmunity, eventually resulting in autoimmune diseases such as rheumatoid arthritis (RA).The authors studied whether...
9.
te Winkel A, van Eijkeren M, van der Laan J
Ned Tijdschr Geneeskd
. 2008 Jun;
152(16):970.
PMID: 18561796
No abstract available.
10.
Putman E, van der Laan J, van Loveren H
Fundam Clin Pharmacol
. 2004 Jan;
17(5):615-26.
PMID: 14703723
Over the last couple of years the assessment of immunotoxic potential of human pharmaceuticals has drawn considerable attention worldwide. Regulatory agencies entrusted with the registration of pharmaceuticals (or other compounds)...