J V Ruderman
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Explore the profile of J V Ruderman including associated specialties, affiliations and a list of published articles.
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54
Citations
2274
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Recent Articles
1.
Topper L, Bastians H, Ruderman J, Gorbsky G
J Cell Biol
. 2001 Aug;
154(4):707-17.
PMID: 11514588
Cdc34/Ubc3 is a ubiquitin-conjugating enzyme that functions in targeting proteins for proteasome-mediated degradation at the G1 to S cell cycle transition. Elevation of Cdc34 protein levels by microinjection of bacterially...
2.
Yam C, Siu W, Kaganovich D, Ruderman J, Poon R
Proc Natl Acad Sci U S A
. 2001 Jan;
98(2):497-501.
PMID: 11136238
Previous work has shown that cyclin A can be cleaved at Arg-70/Arg-71 by a proteolytic activity present in an in vitro-coupled transcription/translation system by using rabbit reticulocyte lysate programmed by...
3.
Tian J, Kim S, Heilig E, Ruderman J
Proc Natl Acad Sci U S A
. 2000 Dec;
97(26):14358-63.
PMID: 11114187
Quiescent full-grown Xenopus oocytes remain arrested at the G(2)/M border of meiosis I until exposed to progesterone, their natural mitogen. Progesterone triggers rapid, nontranscriptional responses that lead to the translational...
4.
Mendez R, Hake L, Andresson T, Littlepage L, Ruderman J, Richter J
Nature
. 2000 Apr;
404(6775):302-7.
PMID: 10749216
Full-grown Xenopus oocytes arrest at the G2/M border of meiosis I. Progesterone breaks this arrest, leading to the resumption of the meiotic cell cycles and maturation of the oocyte into...
5.
Bastians H, Topper L, Gorbsky G, Ruderman J
Mol Biol Cell
. 1999 Nov;
10(11):3927-41.
PMID: 10564281
The ubiquitin-dependent proteolysis of mitotic cyclin B, which is catalyzed by the anaphase-promoting complex/cyclosome (APC/C) and ubiquitin-conjugating enzyme H10 (UbcH10), begins around the time of the metaphase-anaphase transition and continues...
6.
Farruggio D, Townsley F, Ruderman J
Proc Natl Acad Sci U S A
. 1999 Jun;
96(13):7306-11.
PMID: 10377410
Cdc20/fizzy family proteins are involved in activation of the anaphase-promoting complex/cyclosome, which catalyzes the ubiquitin-dependent proteolysis of cell cycle regulatory proteins such as anaphase inhibitors and mitotic cyclins, leading to...
7.
Bastians H, Townsley F, Ruderman J
Proc Natl Acad Sci U S A
. 1998 Dec;
95(26):15374-81.
PMID: 9860976
Progression through the cell cycle is regulated in part by the sequential activation and inactivation of cyclin-dependent kinases (CDKs). Many signals arrest the cell cycle through inhibition of CDKs by...
8.
Arvand A, Bastians H, Welford S, Thompson A, Ruderman J, Denny C
Oncogene
. 1998 Nov;
17(16):2039-45.
PMID: 9798675
The EWS/FLI1 fusion gene found in Ewing's sarcoma and primitive neuroectodermal tumor, is able to transform certain cell lines by acting as an aberrant transcription factor. The ability of EWS/FLI1...
9.
Andresson T, Ruderman J
EMBO J
. 1998 Oct;
17(19):5627-37.
PMID: 9755163
Quiescent Xenopus oocytes are activated by progesterone, which binds to an unidentified surface-associated receptor. Progesterone activates a poorly understood signaling pathway that results in the translational activation of mRNA encoding...
10.
Townsley F, Ruderman J
Trends Cell Biol
. 1998 Aug;
8(6):238-44.
PMID: 9695848
A key player in mitotic progression is a cell-cycle-regulated ubiquitin-protein ligase complex known as the anaphase-promoting complex or cyclosome (APC/C). The APC/C is part of the machinery that promotes the...