J T Knowler
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Explore the profile of J T Knowler including associated specialties, affiliations and a list of published articles.
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48
Citations
182
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Recent Articles
1.
McCord A, Boyle S, Knowler J, Burnett A, Craft J
Chem Biol Interact
. 1996 Jan;
99(1-3):29-40.
PMID: 8620577
The metabolism of polycyclic aromatic hydrocarbons by bone marrow, mononuclear cells from normal donors and leukaemia patients in remission has been investigated. When benz[alpha]anthracene (BA) was included with marrow under...
2.
Ross B, Mclaughlin M, Roberts M, Milligan G, McCulloch J, Knowler J
Brain Res
. 1993 Sep;
622(1-2):35-42.
PMID: 8242380
The aim of this study was to assess the effect of Alzheimer's disease has on the functional integrity of several signal transduction proteins. The relative levels of the G-protein alpha...
3.
Ross B, Knowler J, McCulloch J
J Neurochem
. 1992 May;
58(5):1810-9.
PMID: 1560235
The levels of the mRNAs encoding the G protein subunits GS alpha, G beta 1, and G beta 2 were measured by northern blotting in the frontal cortex and hippocampus...
4.
Bhatt A, Knowler J
Eur J Biochem
. 1992 Mar;
204(3):971-5.
PMID: 1372555
Starch phosphorylase has been cloned from a lambda gt10 cDNA library of potato tuber mRNA. Selected recombinants have been used to demonstrate that phosphorylase mRNA is most abundant in tubers...
5.
Mclaughlin M, Ross B, Milligan G, McCulloch J, Knowler J
J Neurochem
. 1991 Jul;
57(1):9-14.
PMID: 1904911
Many of the neurotransmitter systems that are altered in senile dementia of the Alzheimer type are known to mediate their effects via G proteins, yet the integrity of guanine nucleotide-binding...
6.
Griffiths S, Knowler J, Houslay M
Eur J Biochem
. 1990 Oct;
193(2):367-74.
PMID: 1699758
Synthetic oligonucleotide probes were designed to detect the alpha-subunits of the guanine-nucleotide-regulatory proteins (G-proteins) Gi-1, Gi-2, Gi-3 and Gs (Gi is inhibitory and Gs is stimulatory). Each probe detected a...
7.
Bushfield M, Griffiths S, Murphy G, Pyne N, Knowler J, Milligan G, et al.
Biochem J
. 1990 Oct;
271(2):365-72.
PMID: 1700700
Levels of the G-protein alpha-subunits alpha-Gi-2, alpha-Gi-3 and the 42 kDa, form of alpha-Gs were markedly decreased in hepatocyte membranes from streptozotocin-diabetic animals as compared with normals. In contrast, no...
8.
Jones L, Knowler J
J Neurochem
. 1989 Nov;
53(5):1341-4.
PMID: 2795004
It has been suggested that defects in the relationship between ribonuclease and its proteinaceous inhibitor could be a contributory factor in Alzheimer's disease. We have investigated this possibility further by...
9.
Mitchell F, Griffiths S, Saggerson E, Houslay M, Knowler J, Milligan G
Biochem J
. 1989 Sep;
262(2):403-8.
PMID: 2508627
Considerable debate has focused on the molecular identity of the guanine-nucleotide-binding proteins (G-proteins) in adipose tissue which can be detected following pertussis-toxin-catalysed ADP-ribosylation [Rapiejko, Northup, Evans, Brown & Malbon (1986)...
10.
Travers M, Wakeling A, Knowler J
Mol Cell Endocrinol
. 1988 Jun;
57(3):179-86.
PMID: 2456961
We have previously shown that oestrogen elicits profound effects on the mRNA population of the immature rat uterus. In order to follow these responses in a more precise manner, we...