J T Elder
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Explore the profile of J T Elder including associated specialties, affiliations and a list of published articles.
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98
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1920
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Recent Articles
1.
Enerback C, Sandin C, Lambert S, Zawistowski M, Stuart P, Verma D, et al.
Sci Rep
. 2018 May;
8(1):7043.
PMID: 29728633
Tyrosine kinase 2 (TYK2) belongs to the Janus kinase (JAK) family of tyrosine kinases, which transmit signals from activated cytokine receptors. GWAS have consistently implicated TYK2 in psoriasis susceptibility. We...
2.
Molinuevo R, Freije A, de Pedro I, Stoll S, Elder J, Gandarillas A
Oncogene
. 2016 Jul;
36(7):956-965.
PMID: 27452522
Tumour suppressor p53 or proto-oncogene MYC is frequently altered in squamous carcinomas, but this is insufficient to drive carcinogenesis. We have shown that overactivation of MYC or loss of p53...
3.
Stoll S, Stuart P, Swindell W, Tsoi L, Li B, Gandarillas A, et al.
Oncogene
. 2015 Aug;
35(16):2075-86.
PMID: 26234682
Epidermal growth factor receptor (EGFR) is central to epithelial cell physiology, and deregulated EGFR signaling has an important role in a variety of human carcinomas. Here we show that silencing...
4.
Shaiq P, Stuart P, Latif A, Schmotzer C, Kazmi A, Khan M, et al.
Br J Dermatol
. 2013 Mar;
169(2):406-11.
PMID: 23495851
Background: Genetic predisposition to psoriasis, an inflammatory skin disease affecting 0·2-4% of the world population, is well established. Thus far, 41 psoriasis susceptibility loci reach genome-wide significance (P ≤ 5...
5.
Stuart P, Nair R, Hiremagalore R, Kullavanijaya P, Tejasvi T, Lim H, et al.
Tissue Antigens
. 2010 Jul;
76(5):387-97.
PMID: 20604894
Earlier studies have shown that psoriasis in Japan and Thailand is associated with two different major histocompatibility complex (MHC) haplotypes - those bearing HLA-Cw6 and those bearing HLA-Cw1 and HLA-B46....
6.
Elder J
Genes Immun
. 2009 Mar;
10(3):201-9.
PMID: 19262574
Psoriasis is a common, immunologically mediated, inflammatory and hyperproliferative disease of the skin and joints, with a multifactorial genetic basis. We earlier mapped PSORS1, the major psoriasis susceptibility gene in...
7.
Johnston A, Arnadottir S, Gudjonsson J, Aphale A, Sigmarsdottir A, Gunnarsson S, et al.
Br J Dermatol
. 2008 Jun;
159(2):342-50.
PMID: 18547319
Background: Obesity is a significant risk factor for psoriasis and body mass index (BMI) correlates with disease severity. Objectives To investigate the relationship between obesity and psoriasis, focusing on the...
8.
Stuart P, Nair R, Abecasis G, Nistor I, Hiremagalore R, Chia N, et al.
J Med Genet
. 2005 Jun;
43(1):12-7.
PMID: 15923274
Background: A previous study identified two peaks of allelic association between psoriasis and single nucleotide polymorphisms (SNPs) mapping to distal chromosome 17q, including a disease associated SNP that leads to...
9.
Varani J, Lateef H, Fay K, Elder J
Skin Pharmacol Physiol
. 2005 May;
18(3):123-31.
PMID: 15897684
Psoriatic plaque skin incubated for eight days in organ culture in the presence of a potent epidermal growth factor (EGF) receptor tyrosine kinase (RTK) antagonist reverted to a more normal...
10.
Rahman P, Elder J
Ann Rheum Dis
. 2005 Feb;
64 Suppl 2:ii37-9.
PMID: 15708933
Psoriasis and psoriatic arthritis (PsA) are interrelated disorders, as most patients with PsA also have psoriasis. Thus it is not surprising that epidemiological and immunogenetic studies have uncovered important links...