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J Sprouse

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Articles 11
Citations 429
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Recent Articles
1.
Kessler E, Sprouse J, Harrington M
Neuroscience . 2008 Jun; 154(4):1187-94. PMID: 18538936
Health problems can arise from de-synchrony between the external environment and the endogenous circadian rhythm, yet the circadian system is not able to quickly adjust to large, abrupt changes in...
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SMATHERS S, Wallner K, Sprouse J, True L
Int J Radiat Oncol Biol Phys . 2001 Aug; 50(5):1207-11. PMID: 11483330
Purpose: The long-standing confusion regarding the clinical relevance of postimplant biopsies is complicated by the common occurrence of temporary PSA rises between 1 and 2 years after brachytherapy. We report...
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Sprouse J, Braselton J, Reynolds L, Clarke T, Rollema H
Synapse . 2001 May; 41(1):49-57. PMID: 11354013
Systemic doses of fluoxetine slow dorsal raphe cell firing by blocking the reuptake carrier located in the cell body region with the surplus 5-HT thus generated activating inhibitory autoreceptors. The...
4.
Sprouse J, Braselton J, Reynolds L
Biol Psychiatry . 2000 Jun; 47(12):1050-5. PMID: 10862804
Background: The ability of pindolol to block 5-HT(1A) autoreceptors on serotonin-containing neurons in the raphe nuclei is thought to underlie the clinical reports of enhanced efficacy and rate of improvement...
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Sprouse J, Reynolds L, Rollema H
Neuropharmacology . 1997 Apr; 36(4-5):559-67. PMID: 9225281
GR127935 is a selective antagonist of release-modulating 5-HT1B/1D autoreceptors on serotonergic terminals and, as such, would be expected to produce increases in extracellular 5-HT. The changes in 5-HT observed are...
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Schulz D, Mansbach R, Sprouse J, Braselton J, Collins J, Corman M, et al.
Proc Natl Acad Sci U S A . 1996 Sep; 93(19):10477-82. PMID: 8816826
Here we describe the properties of CP-154,526, a potent and selective nonpeptide antagonist of corticotropin (ACTH) releasing factor (CRF) receptors. CP-154,526 binds with high affinity to CRF receptors (Ki <...
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Sprouse J, Clarke T, Reynolds L, Heym J, Rollema H
Neuropsychopharmacology . 1996 Apr; 14(4):225-31. PMID: 8924190
N-demethylation of the selective serotonin reuptake inhibitor sertraline to desmethylsertraline yields a compound with 10- to 20-fold less potency at blocking serotonin (5-HT) reuptake as measured in vitro. In the...
10.
Livingstone L, White A, Sprouse J, Livanos E, Jacks T, Tlsty T
Cell . 1992 Sep; 70(6):923-35. PMID: 1356076
Gene amplification occurs at high frequency in transformed cells (10(-3)-10(-5)), but is undetectable in normal diploid fibroblasts (less than 10(-9)). This study examines whether alterations of one or both p53...