J Sawynok
Overview
Explore the profile of J Sawynok including associated specialties, affiliations and a list of published articles.
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Articles
98
Citations
1123
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Recent Articles
1.
Sawynok J
Neuroscience
. 2015 Oct;
338:1-18.
PMID: 26500181
The main focus for the development of adenosine targets as analgesics to date has been ARs due to its antinociceptive profile in various preclinical pain models. The usefulness of systemic...
2.
Sawynok J
Eur J Pain
. 2013 Oct;
18(4):465-81.
PMID: 24108446
Topical analgesics applied locally to skin or to specialized compartments modify pain by actions on sensory nerve endings and/or adjacent cellular elements. With this approach, there are low systemic drug...
3.
Sawynok J
Handb Exp Pharmacol
. 2006 Nov;
(177):309-28.
PMID: 17087128
Adenosine and ATP, via P1 and P2 receptors respectively, can modulate pain transmission under physiological, inflammatory, and neuropathic pain conditions. Such influences reflect peripheral and central actions and effects on...
4.
Aumeerally N, Allen G, Sawynok J
Neuroscience
. 2004 Jun;
127(1):1-11.
PMID: 15219663
Glutamate (which facilitates peripheral nociception) releases adenosine (which inhibits peripheral nociception via adenosine A(1) receptors) when injected locally into the rat hindpaw. The present study determined whether this locally released...
5.
Lynch M, Clark A, Sawynok J
Clin J Pain
. 2003 Sep;
19(5):323-8.
PMID: 12966259
Objective: The involvement of ongoing peripheral activity in the generation of nociceptive input in neuropathic pain suggests that topical drug delivery may be useful as a treatment strategy. This is...
6.
Liu X, White T, Sawynok J
Neuroscience
. 2002 Sep;
114(2):379-87.
PMID: 12204207
Modulation of endogenous adenosine levels by inhibition of adenosine metabolism produces a peripheral antinociceptive effect in a neuropathic pain model. The present study used microdialysis to investigate the neuronal mechanisms...
7.
Esser M, Chase T, ALLEN G, Sawynok J
Eur J Pharmacol
. 2001 Nov;
430(2-3):211-8.
PMID: 11711033
This study was designed to determine (1) whether chronic amitriptyline administration was effective in alleviating symptoms of neuropathic pain in a rat model of spinal nerve injury, and (2) whether...
8.
Liu X, White T, Sawynok J
Eur J Pharmacol
. 2001 Nov;
429(1-3):147-55.
PMID: 11698037
Injection of formalin into the rat hind paw produces a dose-dependent local peripheral release of adenosine. Low doses of formalin (0.5-2.5%) evoke release during the first 10 min following injection,...
9.
Sawynok J, Esser M, Reid A
J Psychiatry Neurosci
. 2001 Feb;
26(1):21-9.
PMID: 11212590
Antidepressants, given systemically, are widely used for the treatment of various chronic and neuropathic pain conditions in humans. In animal studies, antidepressants exhibit analgesic properties in nociceptive, inflammatory and neuropathic...
10.