J S Beckmann
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Explore the profile of J S Beckmann including associated specialties, affiliations and a list of published articles.
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165
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5105
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Recent Articles
11.
Soller M, Beckmann J
Theor Appl Genet
. 2013 Nov;
74(3):369-78.
PMID: 24241675
This study explores the theoretical potential of "insertional mutagenesis" (i.e., mutagenesis as a result of integration of novel DNA sequences into the germ line), as a means of cloning quantitative...
12.
Lebowitz R, Soller M, Beckmann J
Theor Appl Genet
. 2013 Nov;
73(4):556-62.
PMID: 24241113
Methods are presented for determining linkage between a marker locus and a nearby locus affecting a quantitative trait (quantitative trait locus=QTL), based on changes in the marker allele frequencies in...
13.
Beckmann J, Soller M
Theor Appl Genet
. 2013 Nov;
76(2):228-36.
PMID: 24232110
By making use of pedigree information and information on marker-genotypes of the parent and F-1 individuals crossed to form an F-2 population, it is possible to carry out a linkage...
14.
Soller M, Beckmann J
Theor Appl Genet
. 2013 Nov;
80(2):205-8.
PMID: 24220897
When heritability of the trait under investigation is low, replicated progenies can bring about a major reduction in the number of individuals that need to be scored for marker genotype...
15.
Phan-Hug F, Beckmann J, Jacquemont S
Best Pract Res Clin Endocrinol Metab
. 2012 Apr;
26(2):133-43.
PMID: 22498244
The obesity epidemic is associated with the recent availability of highly palatable and inexpensive caloric food as well as important changes in lifestyle. Genetic factors, however, play a key role...
16.
Walters R, Jacquemont S, Valsesia A, de Smith A, Martinet D, Andersson J, et al.
Nature
. 2010 Feb;
463(7281):671-5.
PMID: 20130649
Obesity has become a major worldwide challenge to public health, owing to an interaction between the Western 'obesogenic' environment and a strong genetic contribution. Recent extensive genome-wide association studies (GWASs)...
17.
Abdelli S, Puyal J, Bielmann C, Buchillier V, Abderrahmani A, Clarke P, et al.
Diabetologia
. 2009 Jul;
52(9):1871-80.
PMID: 19609503
Aims/hypothesis: In insulin-secreting cells, activation of the c-Jun NH(2)-terminal kinase (JNK) pathway triggers apoptosis. Whereas JNK1 and JNK2 are ubiquitously produced, JNK3 has been described exclusively in neurons. This report...
18.
Sevin M, Kutalik Z, Bergman S, Vercelletto M, Renou P, Lamy E, et al.
J Med Genet
. 2009 Jun;
46(12):818-24.
PMID: 19542082
Background: Male carriers of the FMR1 premutation are at risk of developing the fragile X-associated tremor/ataxia syndrome (FXTAS), a newly recognised and largely under-diagnosed late onset neurodegenerative disorder. Patients affected...
19.
Flahaut M, Meier R, Coulon A, Nardou K, Niggli F, Martinet D, et al.
Oncogene
. 2009 May;
28(23):2245-56.
PMID: 19421142
The development of chemoresistance represents a major obstacle in the successful treatment of cancers such as neuroblastoma (NB), a particularly aggressive childhood solid tumour. The mechanisms underlying the chemoresistant phenotype...
20.
Beckmann J, Sharp A, Antonarakis S
Cytogenet Genome Res
. 2009 Mar;
123(1-4):7-16.
PMID: 19287134
The extensive variability of individual human genomes contributes to phenotypic variability. Structural genomic variants, and copy number variants (CNVs) in particular, have recently been rediscovered as contributors to the genomic...