J Robert McCorkle
Overview
Explore the profile of J Robert McCorkle including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
242
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Recent Articles
1.
Gukathasan S, Olelewe C, Ratliff L, Kim J, Ackerman A, McCorkle J, et al.
J Med Chem
. 2025 Feb;
68(5):5687-5698.
PMID: 39979117
In this work, we discovered a novel organometallic gold(III) macrocycle, that demonstrates anticancer potency in a panel of triple-negative breast cancer cells (TNBC), and based on this complex, a biotinylated-Au-Mac1...
2.
Neupane K, Aryal S, Harvey B, Ramon G, Chun B, McCorkle J, et al.
Adv Healthc Mater
. 2024 Sep;
13(30):e2401906.
PMID: 39240019
Tumor-associated macrophages (TAMs) represent the majority of the immune cells present in the tumor microenvironment. These macrophages exhibit an anti-inflammatory (M2)-like physiological state and execute immune-suppressive and tumor-supporting properties. With...
3.
McCorkle J, Ahn R, Cao C, Hill K, Dietrich C, Kolesar J
Cancers (Basel)
. 2024 Apr;
16(7).
PMID: 38610999
Artesunate belongs to a class of medications derived from the sweet wormwood plant () known as artemisinins. Artesunate has traditionally been used as a frontline treatment for severe malaria but...
4.
Neupane K, Ramon G, Harvey B, Chun B, Aryal S, Masud A, et al.
Adv Healthc Mater
. 2023 Jun;
12(27):e2301163.
PMID: 37377147
Tumor-associated macrophages are the predominant immune cells present in the tumor microenvironment and mostly exhibit a pro-tumoral M2-like phenotype. However, macrophage biology is reversible allowing them to acquire an anti-tumoral...
5.
Schweer D, Anand N, Anderson A, McCorkle J, Neupane K, Nail A, et al.
Front Oncol
. 2023 Jan;
12:1042730.
PMID: 36713536
Background: Ovarian cancer is a deadly female malignancy with a high rate of recurrent and chemotherapy-resistant disease. Tumor-associated macrophages (TAMs) are a significant component of the tumor microenvironment and include...
6.
Bhosale S, Mandal A, Hou C, McCorkle J, Schweer D, Hill K, et al.
ChemMedChem
. 2022 Nov;
18(3):e202200368.
PMID: 36342449
DNA coordinating platinum (Pt) containing compounds cisplatin and carboplatin have been used for the treatment of ovarian cancer therapy for four decades. However, recurrent Pt-resistant cancers are a major cause...
7.
Ferguson D, McCorkle J, Barnett K, Bonten E, Bergeron B, Bhattarai K, et al.
Blood Adv
. 2022 Jun;
6(11):3386-3397.
PMID: 35671062
Understanding the genomic and epigenetic mechanisms of drug resistance in pediatric acute lymphoblastic leukemia (ALL) is critical for further improvements in treatment outcomes. The role of transcriptomic response in conferring...
8.
Gorski J, Zhang Z, McCorkle J, DeJohn J, Wang C, Miller R, et al.
Biomedicines
. 2021 Aug;
9(8).
PMID: 34440225
The development of patient-derived tumor organoids (TOs) from an epithelial ovarian cancer tumor obtained at the time of primary or interval debulking surgery has the potential to play an important...
9.
McCorkle J, Gorski J, Liu J, Riggs M, McDowell A, Lin N, et al.
PLoS One
. 2021 Aug;
16(8):e0254205.
PMID: 34347777
Conventional frontline treatment for ovarian cancer consists of successive chemotherapy cycles of paclitaxel and platinum. Despite the initial favorable responses for most patients, chemotherapy resistance frequently leads to recurrent or...
10.
Hill K, McDowell A, McCorkle J, Schuler E, Ellingson S, Plattner R, et al.
Cancers (Basel)
. 2021 Apr;
13(8).
PMID: 33920029
Artesunate is the most common treatment for malaria throughout the world. Artesunate has anticancer activity likely through the induction of reactive oxygen species, the same mechanism of action utilized in...