J R Mercer
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Explore the profile of J R Mercer including associated specialties, affiliations and a list of published articles.
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Articles
46
Citations
214
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Recent Articles
1.
El-Mabhouh A, Nation P, Abele J, Riauka T, Postema E, McEwan A, et al.
Oncol Res
. 2011 Jul;
19(6):287-95.
PMID: 21776824
Bone metastases in advanced breast cancer patients remains a significant treatment challenge. Bisphosphonates are now a routine first line treatment for prevention and treatment of skeletal damage caused by malignancies...
2.
El-Mabhouh A, Nation P, Kaddoura A, Mercer J
Vet Pathol
. 2008 Nov;
45(6):941-4.
PMID: 18984801
Animal models are useful tools to study etiology, progress, and new treatments of disease and are an approximation of human disease for experimental study. Intracardiac injection of the human estrogen-independent...
3.
Xiao Z, McQuarrie S, Suresh M, Mercer J, Gupta S, Miller G
J Biotechnol
. 2002 Feb;
94(2):171-84.
PMID: 11796170
To improve tumor-to-tissue ratios of anticancer agents in radioimmunotherapy, a three-step targeting approach was used to deliver biotinylated liposomes to human ovarian cancer cells (NIH:OVCAR-3, SK-OV-3) in vitro. Targeting was...
4.
Stypinski D, McQuarrie S, Wiebe L, Tam Y, Mercer J, McEwan A
J Nucl Med
. 2001 Sep;
42(9):1418-23.
PMID: 11535735
Unlabelled: 123I-Labeled iodoazomycin arabinoside (IAZA) is a marker of hypoxia in vivo. It has been used clinically to image hypoxic tissue in solid tumors, peripheral vascular disease of diabetic origin,...
5.
McQuarrie S, Xiao Z, Miller G, Mercer J, Suresh M
Q J Nucl Med
. 2001 Jul;
45(2):160-6.
PMID: 11476165
A review of published data on some of the problems associated in treating cancer using radioimmunotherapy is presented. Potential improvements for this type of therapy using pretargeting strategies are discussed...
6.
Mercer J, Duke M, McQuarrie S
Appl Radiat Isot
. 2000 Jun;
52(6):1413-7.
PMID: 10855670
The radionuclide 41Ar has many ideal properties as a gas flow tracer. However, the modest cross-section of 40Ar for thermal neutron activation makes preparation of suitable activities of 41Ar technically...
7.
Lee H, Kumar P, McEwan A, Wiebe L, Mercer J
Nucl Med Biol
. 2000 Apr;
27(1):61-8.
PMID: 10755647
Scintigraphic evaluation of patients with advanced oncological disease showed uptake of radioactivity in the brain following administration of the hypoxic imaging agent 123I-iodoazomycin arabinoside (123I-IAZA). Three proposed metabolites of IAZA--methyl...
8.
Stypinski D, Wiebe L, Tam Y, Mercer J, McEwan A
Nucl Med Biol
. 2000 Mar;
26(8):959-65.
PMID: 10708311
Effects of methoxyflurane anesthesia on the pharmacokinetics of intravenous 125I-IAZA in rats are reported. No significant differences in t(1/2alpha), t(1/2beta), V(SS), and ClTB for total radioactivity (125I-IAZA and metabolites) were...
9.
Stypinski D, Wiebe L, McEwan A, SCHMIDT R, Tam Y, Mercer J
Nucl Med Commun
. 1999 Aug;
20(6):559-67.
PMID: 10451869
123I-labelled iodoazomycin arabinoside (123I-IAZA) is an experimental radiopharmaceutical that has been shown to have clinical utility for imaging regional tissue hypoxia. We report the clinical pharmacokinetics of IAZA, the radiopharmacokinetics...
10.
Emami J, Pasutto F, Mercer J, Jamali F
Life Sci
. 1999 Mar;
64(5):325-35.
PMID: 10072192
To elucidate the mechanism by which hydroxychloroquine (HCQ) affects glucose metabolism, the effect of this drug and its enantiomers on insulin metabolism was studied using the cytosolic fraction of liver...