J R Lorsch
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Explore the profile of J R Lorsch including associated specialties, affiliations and a list of published articles.
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9
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Recent Articles
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Lorsch J, Herschlag D
EMBO J
. 1999 Dec;
18(23):6705-17.
PMID: 10581244
Approaches have been developed for the kinetic dissection of eukaryotic translation initiation in vitro using rabbit reticulocyte ribosomes and a crude preparation of initiation factors. These new approaches have allowed...
3.
Lorsch J, Herschlag D
Biochemistry
. 1998 Mar;
37(8):2194-206.
PMID: 9485365
Limited proteolysis experiments have been carried out with the DEAD box protein eIF4A. The results suggest that there is a substantial conformational change in eIF4A upon binding single-stranded RNA. Binding...
4.
Lorsch J, Herschlag D
Biochemistry
. 1998 Mar;
37(8):2180-93.
PMID: 9485364
eIF4A is the archetypal member of the DEAD box family of proteins and has been proposed to use the energy from ATP hydrolysis to unwind structures in the 5'-untranslated regions...
5.
Lorsch J, Szostak J
Acc Chem Res
. 1996 Feb;
29(2):103-10.
PMID: 11539421
In Tom Stoppard's famous play [Rosencrantz and Guildenstern are Dead], the ill-fated heroes toss a coin 101 times. The first 100 times they do so the coin lands heads up....
6.
Lorsch J, Szostak J
Biochemistry
. 1995 Nov;
34(46):15315-27.
PMID: 7578148
We have previously isolated a series of ribozymes with polynucleotide kinase activity [Lorsch, J.R., & Szostak, J.W. (1994) Nature 371, 31-36]. In order to learn how such newly evolved RNAs...
7.
Lorsch J, Bartel D, Szostak J
Nucleic Acids Res
. 1995 Aug;
23(15):2811-4.
PMID: 7544885
Avian myeloblastosis virus and Maloney murine leukemia virus RNase H-reverse transcriptases pause when they encounter a 2'-5' linkage or a 2'-thiophosphate in their template RNAs, but eventually read through these...
8.
Lorsch J, Szostak J
Nature
. 1994 Sep;
371(6492):31-6.
PMID: 7521014
We have isolated a large number of polynucleotide kinase ribozymes from a pool of RNA molecules consisting of an ATP-binding domain flanked by regions of random sequence. Different classes of...
9.
Lorsch J, Szostak J
Biochemistry
. 1994 Feb;
33(4):973-82.
PMID: 7508262
RNA receptors (aptamers) capable of specifically binding cyanocobalamin (vitamin B12) have been isolated by in vitro selection from a pool of 5 x 10(14) RNAs of random sequence. After eight...