J R Giglio
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Explore the profile of J R Giglio including associated specialties, affiliations and a list of published articles.
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104
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788
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Recent Articles
1.
Guimaraes C, Andriao-Escarso S, Moreira-Dill L, Carvalho B, Marchi-Salvador D, Santos-Filho N, et al.
Biomed Res Int
. 2014 Jun;
2014:981923.
PMID: 24901004
Crude venom of Bothrops jararacussu and isolated phospholipases A2 (PLA2) of this toxin (BthTX-I and BthTX-II) were chemically modified (alkylation) by p-bromophenacyl bromide (BPB) in order to study antibody production...
2.
Cusinato D, Souza A, Vasconcelos F, Guimaraes L, Leite F, Gregorio Z, et al.
Toxicon
. 2010 Sep;
56(8):1477-86.
PMID: 20837041
The aim of this work was to evaluate the hematological changes induced by Tityus serrulatus venom (TsV). Blood of Wistar rats was collected 0.5, 2, 6 and 24 h after...
3.
Cintra-Francischinelli M, Silva M, Andreo-Filho N, Gerenutti M, Cintra A, Giglio J, et al.
Phytother Res
. 2008 Apr;
22(6):784-90.
PMID: 18389489
Casearia sylvestris Sw., popularly known in Brazil as 'guaçatonga', has been used as antitumor, antiseptic, antiulcer, local anaesthetic and healer in folk medicine. Snakebite envenomation by Bothrops jararacussu (Bjssu) constitutes...
4.
Tamarozzi M, Soares S, Marcussi S, Giglio J, Barbosa J
Biochim Biophys Acta
. 2006 Jul;
1760(9):1450-7.
PMID: 16828972
Phospholipases A(2) are components of Bothrops venoms responsible for disruption of cell membrane integrity via hydrolysis of its phospholipids. This study used a large nonimmune human scFv library named Griffin.1...
5.
Veronese E, Esmeraldino L, Trombone A, Santana A, Bechara G, Kettelhut I, et al.
Phytomedicine
. 2005 Feb;
12(1-2):123-30.
PMID: 15693719
Partial neutralization of the myotoxic effect of Bothrops jararacussu venom (BV) and two of its myotoxins [bothropstoxin-I (BthTX-I), catalytically inactive, and II (BthTX-II), showing low PLA2 activity], by the lyophilized...
6.
Cecchini A, Soares A, Cecchini R, de Oliveira A, Ward R, Giglio J, et al.
Comp Biochem Physiol C Toxicol Pharmacol
. 2004 Nov;
138(4):429-36.
PMID: 15536050
Myonecrosis, in addition to edema and other biological manifestations, are conspicuous effects of Bothrops snake venoms, some of them caused by phospholipases A(2) (PLA(2)s). Asp49-PLA(2)s are catalytically active, whereas Lys49-PLA(2)s,...
7.
Ketelhut D, de Mello M, Veronese E, Esmeraldino L, Murakami M, Arni R, et al.
Biochimie
. 2003 Dec;
85(10):983-91.
PMID: 14644553
Acidic phospholipase A(2) (PLA(2)) isoforms in snake venoms, particularly those from Bothrops jararacussu, have not been characterized. This article reports the isolation and partial biochemical, functional and structural characterization of...
8.
Watanabe L, Fontes M, Soares A, Giglio J, Arni R
Protein Pept Lett
. 2003 Oct;
10(5):525-30.
PMID: 14561144
Lys49-Phospholipase A2 (Lys49-PLA(2) - EC 3.1.1.4) homologues damage membranes by a Ca2+-independent mechanism which does not involve catalytic activity. Both MjTX-II from Bothrops moojeni and BthTX-I from Bothrops jararacussu are...
9.
Izidoro L, Rodrigues V, Rodrigues R, Ferro E, Hamaguchi A, Giglio J, et al.
Biochimie
. 2003 Sep;
85(7):669-75.
PMID: 14505822
The aqueous extract from the leaves of Casearia mariquitensis (C. m.), a plant found in Brazilian open pastures, was assayed for its ability to inhibit some hematological and hemostatic effects...
10.
Cintra A, Sampaio S, Raghuvir A, Giglio J
J Protein Chem
. 2001 Dec;
20(5):377-82.
PMID: 11732689
Bothropstoxin-I (BthTX-I), a Lys49 phospholipase A2 homolog with no apparent catalytic activity, was first isolated from Bothropsjararacussu snake venom and completely sequenced in this laboratory. It is a 121-amino-acid single...