J Paul Chapple
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Explore the profile of J Paul Chapple including associated specialties, affiliations and a list of published articles.
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62
Citations
2358
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Recent Articles
11.
Callender L, Schroth J, Carroll E, Garrod-Ketchley C, Romano L, Hendy E, et al.
Nat Commun
. 2021 Jun;
12(1):3379.
PMID: 34099719
GATA3 is as a lineage-specific transcription factor that drives the differentiation of CD4 T helper 2 (Th2) cells, but is also involved in a variety of processes such as immune...
12.
Thompson C, McFie M, Chapple J, Beales P, Knight M
Int J Mol Sci
. 2021 Apr;
22(9).
PMID: 33919210
Primary cilia and associated intraflagellar transport are essential for skeletal development, joint homeostasis, and the response to mechanical stimuli, although the mechanisms remain unclear. Polycystin-2 (PC2) is a member of...
13.
Desai R, East D, Hardy L, Faccenda D, Rigon M, Crosby J, et al.
Sci Adv
. 2020 Dec;
6(51).
PMID: 33355129
Mitochondria drive cellular adaptation to stress by retro-communicating with the nucleus. This process is known as mitochondrial retrograde response (MRR) and is induced by mitochondrial dysfunction. MRR results in the...
14.
Athanasiou D, Bevilacqua D, Aguila M, McCulley C, Kanuga N, Iwawaki T, et al.
Hum Mol Genet
. 2020 Sep;
29(19):3338-3339.
PMID: 32984884
No abstract available.
15.
OToole S, Watson D, Novoselova T, Romano L, King P, Bradshaw T, et al.
Endocr Relat Cancer
. 2018 Oct;
26(1):165-180.
PMID: 30345732
Primary cilia are sensory organelles involved in regulation of cellular signaling. Cilia loss is frequently observed in tumors; yet, the responsible mechanisms and consequences for tumorigenesis remain unclear. We demonstrate...
16.
Parkinson M, Bartmann A, Clayton L, Nethisinghe S, Pfundt R, Chapple J, et al.
Brain
. 2018 Mar;
141(4):989-999.
PMID: 29538656
Autosomal recessive spastic ataxia of Charlevoix-Saguenay is a rare neurodegenerative disorder caused by mutations in the SACS gene. Thickened retinal nerve fibres visible on fundoscopy have previously been described in...
17.
Schwarz N, Lane A, Jovanovic K, Parfitt D, Aguila M, Thompson C, et al.
Hum Mol Genet
. 2017 Sep;
26(17):3451.
PMID: 28854704
No abstract available.
18.
Duncan E, Lariviere R, Bradshaw T, Longo F, Sgarioto N, Hayes M, et al.
Hum Mol Genet
. 2017 May;
26(16):3130-3143.
PMID: 28535259
Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS) is caused by mutations in the gene SACS, encoding the 520 kDa protein sacsin. Although sacsin's physiological role is largely unknown, its sequence...
19.
Zhang J, Dalbay M, Luo X, Vrij E, Barbieri D, Moroni L, et al.
Acta Biomater
. 2017 May;
57:487-497.
PMID: 28456657
Statement Of Significance: The surface topography of synthetic biomaterials plays important roles in material-driven osteogenesis. The data presented herein have shown that the surface topography of calcium phosphate ceramics regulates...
20.
Schwarz N, Lane A, Jovanovic K, Parfitt D, Aguila M, Thompson C, et al.
Hum Mol Genet
. 2017 Apr;
26(13):2480-2492.
PMID: 28444310
Ciliary trafficking defects are the underlying cause of many ciliopathies, including Retinitis Pigmentosa (RP). Anterograde intraflagellar transport (IFT) is mediated by kinesin motor proteins; however, the function of the homodimeric...