J P Mornon
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Explore the profile of J P Mornon including associated specialties, affiliations and a list of published articles.
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99
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2288
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Recent Articles
1.
Mornon J, Prat K, Dupuis F, Boisset N, Callebaut I
Cell Mol Life Sci
. 2003 Feb;
59(12):2144-54.
PMID: 12568340
Prion diseases are neurodegenerative disorders associated with a conformational conversion of the prion PrP protein, in which the beta strand content increases and that of the a helix decreases. However,...
2.
Mornon J, Prat K, Dupuis F, Callebaut I
Cell Mol Life Sci
. 2002 Oct;
59(8):1366-76.
PMID: 12363039
Animal prion proteins (PrPs) form at the sequence level a very homogenous and 'closed' family. Therefore, few of their structural and functional features can be gleaned from sequence comparison as...
3.
Levivier E, Goud B, Souchet M, Calmels T, Mornon J, Callebaut I
Biochem Biophys Res Commun
. 2001 Sep;
287(3):688-95.
PMID: 11563850
DENN domains are found in a variety of signaling proteins but their exact function remains undefined. Some of the DENN-containing proteins, such as rat Rab3GEP (Rab3 GDP/GTP exchange protein) or...
4.
Brooks D, Fabrega S, Hein L, Parkinson E, Durand P, Yogalingam G, et al.
Glycobiology
. 2001 Sep;
11(9):741-50.
PMID: 11555618
Mucopolysaccharidosis type I (MPS I; McKusick 25280) results from a deficiency in alpha-L-iduronidase activity. Using a bioinformatics approach, we have previously predicted the putative acid/base catalyst and nucleophile residues in...
5.
Lamarine M, Mornon J, Berezovsky N, Chomilier J
Cell Mol Life Sci
. 2001 Apr;
58(3):492-8.
PMID: 11315195
Using a set of 372 proteins representative of a variety of 56 distinct globular folds, a statistical correlation was observed between two recently revealed features of protein structures: tightened end...
6.
Callebaut I, Poupon A, Bally R, Demaret J, Housset D, Delettre J, et al.
Ann N Y Acad Sci
. 2001 Feb;
923:90-112.
PMID: 11193783
Uteroglobin (UTG) forms a fascinating homodimeric structure that binds small- to medium-sized ligands through an internal hydrophobic cavity, located at the interface between the two monomers. Previous studies have shown...
7.
Callebaut I, de Gunzburg J, Goud B, Mornon J
Trends Biochem Sci
. 2001 Feb;
26(2):79-83.
PMID: 11166556
RUN domains are present in several proteins that are linked particularly to the functions of GTPases in the Rap and Rab families. They could hence play an important role in...
8.
Benoist J, Acquaviva C, Callebaut I, Guffon N, Ogier de Baulny H, Mornon J, et al.
Mol Genet Metab
. 2001 Feb;
72(2):181-4.
PMID: 11161845
Inherited defects in the gene encoding the methylmalonyl-CoA mutase (MCM) result in the mut forms of methylmalonic aciduria (MMA). Twelve mutations have been identified associated with the mut(-) phenotype. We...
9.
Bouchard P, Chomilier J, Ravet V, Mornon J, Vigues B
J Cell Sci
. 2000 Dec;
114(Pt 1):101-110.
PMID: 11112694
Epiplasmin C is the major protein component of the membrane skeleton in the ciliate Tetrahymena pyriformis. Cloning and analysis of the gene encoding epiplasmin C showed this protein to be...
10.
Fabrega S, Durand P, Codogno P, Bauvy C, Delomenie C, Henrissat B, et al.
Glycobiology
. 2000 Nov;
10(11):1217-24.
PMID: 11087714
Using bioinformatics methods, we have previously identified Glu235 and Glu340 as the putative acid/base catalyst and nucleophile, respectively, in the active site of human glucocerebrosidase. Thus, we undertook site-directed mutagenesis...