J P McGrath
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Explore the profile of J P McGrath including associated specialties, affiliations and a list of published articles.
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44
Citations
1659
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Recent Articles
21.
Williams P, Laska D, Shetler T, McGrath J, White S, Hoover D
Agents Actions
. 1991 Mar;
32(3-4):217-23.
PMID: 1713735
Rapid intravenous administration of the glycopeptide antibiotic, vancomycin, may cause a hypotensive reaction which can usually be prevented by infusing vancomycin in dilute solutions. The release of histamine from circulating...
22.
McGrath J, Jentsch S, Varshavsky A
EMBO J
. 1991 Jan;
10(1):227-36.
PMID: 1989885
All known functions of ubiquitin are mediated through its covalent attachment to other proteins. The post-translational formation of ubiquitin--protein conjugates is preceded by an ATP-requiring step in which the carboxyl...
23.
Seufert W, McGrath J, Jentsch S
EMBO J
. 1990 Dec;
9(13):4535-41.
PMID: 2265617
The covalent attachment of ubiquitin to cellular proteins is catalyzed by members of a family of ubiquitin-conjugating enzymes. These enzymes participate in a variety of cellular processes, including selective protein...
24.
Hoover D, Gardner J, Timmerman T, Klepfer J, Laska D, White S, et al.
Fundam Appl Toxicol
. 1990 Apr;
14(3):589-97.
PMID: 2340986
The venous irritation potential of four parenteral antibiotics, tetracycline hydrochloride (TET), erythromycin lactobionate (ERY), amphotericin B (AMP), and cephaloridine (CEP), was evaluated in an in vivo model using the rabbit...
25.
Probst K, Higdon G, Fisher L, McGrath J, Adams E, EMMERSON J
Fundam Appl Toxicol
. 1989 Nov;
13(4):778-92.
PMID: 2576009
Nizatidine (NIZ), a new antiulcer drug, was evaluated for toxicity in acute, subchronic, and chronic tests. Acute toxicity studies were conducted in rats, mice, dogs, and monkeys. Median lethal doses...
26.
McGrath J, Varshavsky A
Nature
. 1989 Aug;
340(6232):400-4.
PMID: 2569166
Mammalian tumours displaying multidrug resistance overexpress a plasma membrane protein (P-glycoprotein), which is encoded by the MDR1 gene and apparently functions as an energy-dependent drug efflux pump. Tissue-specific expression of...
27.
Goebl M, Yochem J, Jentsch S, McGrath J, Varshavsky A, Byers B
Science
. 1988 Sep;
241(4871):1331-5.
PMID: 2842867
Mutants in the gene CDC34 of the yeast Saccharomyces cerevisiae are defective in the transition from G1 to the S phase of the cell cycle. This gene was cloned and...
28.
Jentsch S, McGrath J, Varshavsky A
Nature
. 1987 Sep;
329(6135):131-4.
PMID: 3306404
The RAD6 gene of the yeast Saccharomyces cerevisiae is required for a variety of cellular functions including DNA repair. The discovery that the RAD6 gene product can catalyse the covalent...
29.
Clark S, McGrath J, Levinson A
Mol Cell Biol
. 1985 Oct;
5(10):2746-52.
PMID: 3939254
We expressed normal and activated human cellular Ha-ras cDNAs which encode 21,000-dalton polypeptides (p21s) in Saccharomyces cerevisiae by their insertion into a 2 micron-based replicating plasmid vector under 3-phosphoglycerate kinase...
30.
Snyder M, Bishop J, McGrath J, Levinson A
Mol Cell Biol
. 1985 Jul;
5(7):1772-9.
PMID: 3927152
We constructed a mutant, called RSV-SF2, at the ATP-binding site of pp60v-src. In this mutant, lysine-295 is replaced with methionine. SF2 pp60v-src was found to have a half-life similar to...