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J P Castano

Explore the profile of J P Castano including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 56
Citations 421
Followers 0
Related Specialties
Endocrinology
Molecular Biology
Physiology
Top 10 Co-Authors
F Gracia-Navarro
M M Malagon
R M Luque
S Garcia-Navarro
R Torronteras
J R Peinado
A J Martinez-Fuentes
R Vazquez-Martinez
L S Frawley
J L Ramirez
Published In
J Neuroendocrinol
Endocrinology
Ann N Y Acad Sci
Gen Comp Endocrinol
Am J Physiol
Affiliations
Soon will be listed here.
Recent Articles
1.
Splicing machinery is profoundly altered in systemic lupus erythematosus and antiphospholipid syndrome and directly linked to key clinical features
Lopez-Pedrera C, Patino-Trives A, Cerdo T, Ortega-Castro R, Sanchez-Pareja I, Ibanez-Costa A, et al.
J Autoimmun . 2023 Jan; 135:102990. PMID: 36621176
Objectives: To characterize the splicing machinery (SM) of leukocytes from primary antiphospholipid syndrome (APS), systemic lupus erythematosus (SLE) and antiphospholipid syndrome with lupus (APS + SLE) patients, and to assess...
2.
Metabolic Fingerprint of Acromegaly and its Potential Usefulness in Clinical Practice
Biagetti B, Herance J, Ferrer R, Aulinas A, Palomino-Schatzlein M, Mesa J, et al.
J Clin Med . 2019 Sep; 8(10). PMID: 31561638
Insulin-like growth factor-1 (IGF-1) and growth hormone (GH) levels are the main targets for monitoring acromegaly activity, but they are not in close relationship with the clinical course of the...
3.
Multiple signaling pathways convey central and peripheral signals to regulate pituitary function: Lessons from human and non-human primate models
Vazquez-Borrego M, Gahete M, Martinez-Fuentes A, Fuentes-Fayos A, Castano J, Kineman R, et al.
Mol Cell Endocrinol . 2017 Dec; 463:4-22. PMID: 29253530
The anterior pituitary gland is a key organ involved in the control of multiple physiological functions including growth, reproduction, metabolism and stress. These functions are controlled by five distinct hormone-producing...
4.
Translational research in neuroendocrine tumors: pitfalls and opportunities
Capdevila J, Casanovas O, Salazar R, Castellano D, Segura A, Fuster P, et al.
Oncogene . 2016 Sep; 36(14):1899-1907. PMID: 27641330
Interest in research on neuroendocrine tumors (NETs) has grown in the past 10 years, coinciding with improvements in our understanding of the molecular pathogenesis of NETs. In addition, NETs have...
5.
Not So Giants: Mice Lacking Both Somatostatin and Cortistatin Have High GH Levels but Show No Changes in Growth Rate or IGF-1 Levels
Pedraza-Arevalo S, Cordoba-Chacon J, Pozo-Salas A, L-Lopez F, de Lecea L, Gahete M, et al.
Endocrinology . 2015 Apr; 156(6):1958-64. PMID: 25830706
Somatostatin (SST) and cortistatin (CORT) are two highly related neuropeptides involved in the regulation of various endocrine secretions. In particular, SST and CORT are two primary negative regulators of GH...
6.
Gastrointestinal neuroendocrine tumors (NETs): new diagnostic and therapeutic challenges
Castano J, Sundin A, Maecke H, Villabona C, Vazquez-Albertino R, Navarro E, et al.
Cancer Metastasis Rev . 2014 Jan; 33(1):353-9. PMID: 24390486
This paper summarizes the current understanding of the biology of somatostatin receptor (sst), role of immunotherapy in neuroendocrine tumor (NET), new agents for PPRT, and methods to assess response and...
7.
A cellular and molecular basis for the selective desmopressin-induced ACTH release in Cushing disease patients: key role of AVPR1b receptor and potential therapeutic implications
Luque R, Ibanez-Costa A, Lopez-Sanchez L, Jimenez-Reina L, Venegas-Moreno E, Galvez M, et al.
J Clin Endocrinol Metab . 2013 Jul; 98(10):4160-9. PMID: 23884782
Context: Desmopressin is a synthetic agonist of vasopressin receptors (AVPRs). The desmopressin stimulation test is used in the diagnosis and postsurgery prognosis of Cushing disease (CD). However, the cellular and...
8.
Somatostatin dramatically stimulates growth hormone release from primate somatotrophs acting at low doses via somatostatin receptor 5 and cyclic AMP
Cordoba-Chacon J, Gahete M, Culler M, Castano J, Kineman R, Luque R
J Neuroendocrinol . 2011 Dec; 24(3):453-63. PMID: 22129035
Somatostatin and cortistatin have been shown to act directly on pituitary somatotrophs to inhibit growth hormone (GH) release. However, previous results from nonprimate species indicate that these peptides can also...
9.
The new truncated somatostatin receptor variant sst5TMD4 is associated to poor prognosis in breast cancer and increases malignancy in MCF-7 cells
Duran-Prado M, Gahete M, Hergueta-Redondo M, Martinez-Fuentes A, Cordoba-Chacon J, Palacios J, et al.
Oncogene . 2011 Sep; 31(16):2049-61. PMID: 21927030
Somatostatin receptors (sst1-5) are present in different types of tumors, where they inhibit key cellular processes such as proliferation and invasion. Although ssts are densely expressed in breast cancer, especially...
10.
Somatotroph tumor progression during pegvisomant therapy: a clinical and molecular study
Marazuela M, Paniagua A, Gahete M, Lucas T, Alvarez-Escola C, Manzanares R, et al.
J Clin Endocrinol Metab . 2010 Nov; 96(2):E251-9. PMID: 21068147
Context: There is concern that pegvisomant could be associated with a higher risk of tumor growth. The rate and possible determinants of this tumor growth are unknown. Objective: The objective...