J N Wurpel
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Explore the profile of J N Wurpel including associated specialties, affiliations and a list of published articles.
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25
Citations
85
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Recent Articles
1.
Wurpel J
Experientia
. 1994 May;
50(5):475-8.
PMID: 8194584
This study investigates the effect of the gamma-aminobutyric acid (GABAB) agonist, baclofen, on amygdala kindling in adult rats. Baclofen has been reported to be anticonvulsant in a variety of seizure...
2.
Wurpel J, Iyer S
Epilepsia
. 1994 Mar;
35(2):443-9.
PMID: 8156971
The calcium channel blockers verapamil (VPM) and nimodipine (NMD) were administered to adult or immature (16-day-old) rats to determine their effects on amygdala-kindled seizures. The afterdischarge threshold (ADT) kindling rate...
3.
Wurpel J, Hirt P, Bidanset J
Neurotoxicology
. 1993 Jan;
14(4):429-36.
PMID: 7513072
Administration of the organophosphate insecticide, chlorpyrifos to immature rats exerted a proconvulsant effect on seizures induced by kindling. Chlorpyrifos was administered to 16 or 17 day old rats in a...
4.
Muto M, Lobelle Jr F, Bidanset J, Wurpel J
Vet Hum Toxicol
. 1992 Dec;
34(6):498-501.
PMID: 1283795
DURSBAN (DB; active ingredient chlorpyrifos) is a widely-used organophosphate insecticide. The teratogenic and neurotoxic potential of DB was evaluated in rats in utero by exposing embryos on days 0-7 or...
5.
Wurpel J, Sperber E, Moshe S
Epilepsia
. 1992 May;
33(3):439-43.
PMID: 1592017
Infusions of 2-amino-7-phosphonoheptanoic acid (AP7) or ketamine into the substantia nigra pars reticulata (SNPR) of adult rats increase the latency of onset to seizures induced by the convulsant ether flurothyl....
6.
Kwon C, Iqbal M, Wurpel J
J Med Chem
. 1991 Jun;
34(6):1845-9.
PMID: 2061925
Iminohydantoins selectively substituted at position C-5 and their 1-carbobenzoxy derivatives have been synthesized, and their anticonvulsant activity was evaluated in mice. In general, the more lipophilic 1-carbobenzoxy iminohydantoins were more...
7.
Wurpel J, Sperber E, Moshe S
Epilepsy Res
. 1990 Jan;
5(1):1-7.
PMID: 2303019
The possible effectiveness of systemic infusions of baclofen (a GABAB receptor agonist) in the modification of seizures in developing animals has not yet been established. In this report, we studied...
8.
Sperber E, Wurpel J, Moshe S
Brain Res Dev Brain Res
. 1989 May;
47(1):143-6.
PMID: 2544322
The substantia nigra GABA-sensitive system is important for the modification of seizures. In adult rats, nigral infusions of baclofen (GABAB agonist) had no effect on flurothyl seizures. This suggests that...
9.
Sperber E, Wurpel J, Sharpless N, Moshe S
Pharmacol Biochem Behav
. 1989 Apr;
32(4):1067-70.
PMID: 2477863
Concentrations of striatal dopamine (DA), serotonin (5-HT) and their metabolites were measured following infusions of the GABAA receptor agonist, muscimol, or GABAA receptor antagonist, bicuculline, into the substantia nigra (SN)...
10.
Sperber E, Wurpel J, Zhao D, Moshe S
Brain Res
. 1989 Feb;
480(1-2):378-82.
PMID: 2540881
Several studies have implicated the substantia nigra GABAergic system in the mediation of seizures in adult rats. The present study examines whether the different GABA receptors (GABAA and GABAB), are...