J M Castellano
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Explore the profile of J M Castellano including associated specialties, affiliations and a list of published articles.
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1806
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Recent Articles
1.
Cardinal-Fernandez P, Garcia Cuesta E, Barberan J, Varona J, Estirado A, Moreno A, et al.
Rev Esp Quimioter
. 2021 May;
34(4):342-352.
PMID: 34008930
Objective: Spain is one of the European countries most affected by the COVID-19 pandemic. Epidemiologic studies are warranted to improve the disease understanding, evaluate the care procedure and prepare for...
2.
Franssen D, Barroso A, Ruiz-Pino F, Vazquez M, Garcia-Galiano D, Castellano J, et al.
Metabolism
. 2020 Dec;
115:154460.
PMID: 33285180
Background: Reproduction is tightly coupled to body energy and metabolic status. GnRH neurons, master elements and final output pathway for the brain control of reproduction, directly or indirectly receive and...
3.
Sanchez-Garrido M, Ruiz-Pino F, Pozo-Salas A, Castellano J, Vazquez M, Luque R, et al.
Sci Rep
. 2020 Aug;
10(1):13898.
PMID: 32807904
In addition to its essential role in the physiological control of longitudinal growth, growth-hormone (GH) is endowed with relevant metabolic functions, including anabolic actions in muscle, lipolysis in adipose-tissue and...
4.
Vazquez M, Toro C, Castellano J, Ruiz-Pino F, Roa J, Beiroa D, et al.
Nat Commun
. 2018 Oct;
9(1):4194.
PMID: 30305620
Puberty is regulated by epigenetic mechanisms and is highly sensitive to metabolic and nutritional cues. However, the epigenetic pathways mediating the effects of nutrition and obesity on pubertal timing are...
5.
Sanchez-Garrido M, Castellano J, Ruiz-Pino F, Garcia-Galiano D, Manfredi-Lozano M, Leon S, et al.
Endocrinology
. 2013 Jun;
154(9):3387-400.
PMID: 23751873
Body energy stores and metabolic cues influence the onset of puberty. However, the pubertal impact of early nutritional challenges has been only fragmentarily addressed. We evaluated here the consequences, in...
6.
Garcia-Galiano D, Pineda R, Ilhan T, Castellano J, Ruiz-Pino F, Sanchez-Garrido M, et al.
Endocrinology
. 2012 Feb;
153(4):1959-71.
PMID: 22334726
Nesfatin-1, product of the precursor NEFA/nucleobindin2 (NUCB2), was initially identified as anorectic hypothalamic neuropeptide, acting in a leptin-independent manner. In addition to its central role in the control of energy...
7.
Ruscica M, Dozio E, Steffani L, Passafaro L, Mazzer M, Castellano J, et al.
J Endocrinol Invest
. 2011 Jun;
34(10):e362-8.
PMID: 21697647
Background: The 5'-AMP-activated protein kinase (AMPK) plays a fundamental role in regulating energy homeostasis as well as feeding and metabolism, through central and peripheral actions. AMPK is activated by conditions...
8.
Tapia-Gonzalez S, Garcia-Segura L, Tena-Sempere M, Frago L, Castellano J, Fuente-Martin E, et al.
J Neuroendocrinol
. 2011 Feb;
23(4):365-70.
PMID: 21314736
Much attention has been drawn to the possible involvement of hypothalamic inflammation in the pathogenesis of metabolic disorders, especially in response to a high-fat diet. Microglia, the macrophages of the...
9.
Castellano J, Bentsen A, Romero M, Pineda R, Ruiz-Pino F, Garcia-Galiano D, et al.
Am J Physiol Endocrinol Metab
. 2010 Apr;
299(1):E54-61.
PMID: 20407007
Severe inflammatory challenges are frequently coupled to decreased food intake and disruption of reproductive function, the latter via deregulation of different signaling pathways that impinge onto GnRH neurons. Recently, the...
10.
Roa J, Garcia-Galiano D, Varela L, Sanchez-Garrido M, Pineda R, Castellano J, et al.
Endocrinology
. 2009 Sep;
150(11):5016-26.
PMID: 19734277
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that operates as sensor of cellular energy status and effector for its coupling to cell growth and proliferation. At the...