J Leipziger
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Explore the profile of J Leipziger including associated specialties, affiliations and a list of published articles.
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50
Citations
633
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Recent Articles
1.
Vitzthum H, Koch M, Eckermann L, Svendsen S, Berg P, Hubner C, et al.
Nat Commun
. 2023 May;
14(1):3051.
PMID: 37236964
The kidney plays a key role in the correction of systemic acid-base imbalances. Central for this regulation are the intercalated cells in the distal nephron, which secrete acid or base...
2.
Ayasse N, de Bruijn P, Berg P, Sorensen M, Leipziger J
Acta Physiol (Oxf)
. 2017 Dec;
223(1):e13013.
PMID: 29226589
Aim: The "voltage hypothesis" of H secretion states that urinary acidification following increased Na delivery to the collecting duct (CD) is ENaC dependent leading to transepithelial voltage-dependent increase in H...
3.
Jensen I, Larsen C, Leipziger J, Sorensen M
Acta Physiol (Oxf)
. 2016 May;
218(1):49-61.
PMID: 27172453
Aim: High dietary K(+) intake is associated with protection against hypertension. In mammals, acute K(+) intake induces natriuresis and kaliuresis, associated with a marked dephosphorylation of the renal Na(+) /Cl(-)...
4.
de Bruijn P, Bleich M, Praetorius H, Leipziger J
Acta Physiol (Oxf)
. 2014 Nov;
213(1):277-84.
PMID: 25362991
Aims: Extracellular ATP is an important regulator of renal tubular transport. Recently, we found that basolateral ATP markedly inhibits Na(+) and Cl(-) absorption in mouse medullary thick ascending limb (mTAL)...
5.
Hejl J, Skals M, Leipziger J, Praetorius H
Pflugers Arch
. 2012 Nov;
465(4):529-41.
PMID: 23149487
Activation of the complement system evokes cell damage by insertion of membrane attack complexes, which constitute the basis of the pathogenesis of various haemolytic disorders. Recently, we found that haemolysis...
6.
UTP reduces infarct size and improves mice heart function after myocardial infarct via P2Y2 receptor
Cohen R, Shainberg A, Hochhauser E, Cheporko Y, Tobar A, Birk E, et al.
Biochem Pharmacol
. 2011 Aug;
82(9):1126-33.
PMID: 21839729
Pyrimidine nucleotides are signaling molecules, which activate G protein-coupled membrane receptors of the P2Y family. P2Y(2) and P2Y(4) receptors are part of the P2Y family, which is composed of 8...
7.
Golan O, Issan Y, Isak A, Leipziger J, Robaye B, Shainberg A
Biochem Pharmacol
. 2011 Mar;
81(10):1219-27.
PMID: 21376706
Rationale: Extracellular nucleotides have widespread effects and various cell responses. Whereas the effect of a purine nucleotide (ATP) and a pyrimidine nucleotide (UTP) on myocardial infarction has been examined, the...
8.
Sorensen M, Praetorius H, Nykjaer A, Willnow T, Leipziger J
Acta Physiol (Oxf)
. 2010 Oct;
201(1):169-77.
PMID: 20969731
Aim: Corticosteroid binding globulin (CBG) is the high affinity plasma carrier protein for cortisol. It keeps the steroids inactive, prevents them from degradation and defines the amount of free hormone...
9.
Praetorius H, Leipziger J
Acta Physiol (Oxf)
. 2009 May;
197(3):241-51.
PMID: 19432587
Aim: Changes in perfusate flow produce increases in [Ca(2+)](i) in renal epithelial cells. Cultured renal epithelia require primary cilia to sense subtle changes in flow. In perfused kidney tubules this...
10.
Geyti C, Odgaard E, Overgaard M, Jensen M, Leipziger J, Praetorius H
Pflugers Arch
. 2007 Nov;
455(6):1105-17.
PMID: 18026749
Renal epithelia can be provoked mechanically to release nucleotides, which subsequently increases the intracellular Ca(2+) concentration [Ca(2+)](i) through activation of purinergic (P2) receptors. Cultured cells often show spontaneous [Ca(2+)](i) oscillations,...