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J Klostergaard

Explore the profile of J Klostergaard including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 88
Citations 362
Followers 0
Related Specialties
Allergy & Immunology
Oncology
Biochemistry
Top 10 Co-Authors
S P Tomasovic
M E LEROUX
G A GRANGER
T Utsumi
M C Hung
E Auzenne
K Akimaru
G Lopez-Berestein
S A Curley
P Tang
Published In
Cancer Res
Lymphokine Res
J Leukoc Biol
J Natl Cancer Inst
Mol Immunol
Affiliations
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Recent Articles
1.
MRP- and BCL-2-mediated drug resistance in human SCLC: effects of apoptotic sphingolipids in vitro
Khodadadian M, LEROUX M, Auzenne E, Ghosh S, Farquhar D, Evans R, et al.
Lung Cancer . 2009 Feb; 66(1):48-57. PMID: 19195736
Multidrug-resistance-associated protein (MRP) and BCL-2 contribute to drug resistance expressed in SCLC. To establish whether MRP-mediated drug resistance affects sphingolipid (SL)-induced apoptosis in SCLC, we first examined the human SCLC...
2.
Sphingolipids and the sphingosine kinase inhibitor, SKI II, induce BCL-2-independent apoptosis in human prostatic adenocarcinoma cells
LEROUX M, Auzenne E, Evans R, Hail Jr N, Spohn W, Ghosh S, et al.
Prostate . 2007 Sep; 67(15):1699-717. PMID: 17879964
Background: Elevated BCL-2 is one mechanism of therapeutic resistance in prostate cancer (PC), and new approaches are needed to overcome such resistance. Methods: We evaluated the effects of BCL-2 over-expression...
3.
Magnetic resonance imaging-based prospective detection of intraperitoneal human ovarian carcinoma xenografts treatment response
Klostergaard J, Auzenne E, Ghosh S, Farquhar D, Rivera B, Price R
Int J Gynecol Cancer . 2006 Mar; 16 Suppl 1:111-7. PMID: 16515577
The feasibility of applying magnetic resonance imaging (MRI) for conducting prospective studies of intraperitoneal (i.p.) tumor treatment response to chemotherapy and resultant effects on survival in human ovarian carcinoma/nude mouse...
4.
Hyperthermia engages the intrinsic apoptotic pathway by enhancing upstream caspase activation to overcome apoptotic resistance in MCF-7 breast adenocarcinoma cells
Klostergaard J, LEROUX M, Auzenne E, Khodadadian M, Spohn W, Wu J, et al.
J Cell Biochem . 2006 Jan; 98(2):356-69. PMID: 16440323
Febrile hyperthermia enhanced TNF-stimulated apoptosis of MCF-7 cells and overcame resistance in a TNF-resistant, MCF-7 variant (3E9), increasing their TNF-sensitivity by 10- and 100-fold, respectively. In either cell line, the...
5.
Transmembrane TNF (pro-TNF) is palmitoylated
Utsumi T, Takeshige T, Tanaka K, Takami K, Kira Y, Klostergaard J, et al.
FEBS Lett . 2001 Jul; 500(1-2):1-6. PMID: 11434916
Human transmembrane tumor necrosis factor (pro-TNF) was examined for protein acylation. The cDNA encoding pro-TNF was expressed in both COS-1 cells and Sf9 cells and metabolic labeling with [(3)H]myristic or...
6.
Febrile and acute hyperthermia enhance TNF-induced necrosis of murine L929 fibrosarcoma cells via caspase-regulated production of reactive oxygen intermediates
Leroux E, Auzenne E, Weidner D, Wu Z, Donato N, Klostergaard J
J Cell Physiol . 2001 Mar; 187(2):256-63. PMID: 11268005
Previous studies have demonstrated the essential role of TNF-induced reactive oxygen intermediates (ROI) in the necrosis of L929 cells. We investigated the molecular basis for the interaction of hyperthermia and...
7.
Emergence of cisplatin-resistant cells from the OVCAR-3 ovarian carcinoma cell line with p53 mutations, altered tumorigenicity, and increased apoptotic sensitivity to p53 gene replacement
Mujoo K, Zhang L, Klostergaard J, Donato N
Int J Gynecol Cancer . 2001 Mar; 10(2):105-114. PMID: 11240661
Resistance to chemotherapy commonly compromises the treatment of many advanced cancers. Evidence suggests a correlation between chemoresistance and more aggressive tumor growth, possibly through accumulation of additional genetic defects in...
8.
Combined cytotoxic action of paclitaxel and ceramide against the human Tu138 head and neck squamous carcinoma cell line
Mehta S, Blackinton D, Omar I, Kouttab N, Myrick D, Klostergaard J, et al.
Cancer Chemother Pharmacol . 2000 Sep; 46(2):85-92. PMID: 10972477
Purpose: Paclitaxel, a chemotherapeutic agent used in the treatment of recalcitrant ovarian and breast as well as other neoplasms, is being investigated for the treatment of squamous cell carcinoma of...
9.
A part of the transmembrane domain of pro-TNF can function as a cleavable signal sequence that generates a biologically active secretory form of TNF
Ishisaka R, Sato N, Tanaka K, Takeshige T, Iwata H, Klostergaard J, et al.
J Biochem . 1999 Jul; 126(2):413-20. PMID: 10423538
To determine the minimum requirement in the 76-residue leader sequence of pro-tumor necrosis factor (TNF) for membrane translocation across the endoplasmic reticulum (ER) and for the maturation of pro-TNF, we...
10.
Paclitaxel-induced apoptosis in Jurkat, a leukemic T cell line, is enhanced by ceramide
Myrick D, Blackinton D, Klostergaard J, Kouttab N, Maizel A, Wanebo H, et al.
Leuk Res . 1999 Jun; 23(6):569-78. PMID: 10374850
We hypothesized that the lipid second messenger, ceramide, and microtubule-directed chemotherapeutic agents might engage converging pathways in inducing apoptosis. Our studies demonstrated that simultaneous treatment of Jurkat cells with paclitaxel...