J Kevin Hicks
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Explore the profile of J Kevin Hicks including associated specialties, affiliations and a list of published articles.
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71
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1790
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Recent Articles
1.
Ho T, Smith D, Aquilante C, Cicali E, El Rouby N, Hertz D, et al.
Clin Pharmacol Ther
. 2025 Jan;
PMID: 39887719
The safety of systemic fluoropyrimidines (e.g., 5-fluorouracil, capecitabine) is impacted by germline genetic variants in DPYD, which encodes the dihydropyrimidine dehydrogenase (DPD) enzyme that functions as the rate-limiting step in...
2.
Donnelly R, Cavallari L, McCune J, Trofe-Clark J, Formea C, Hoffecker G, et al.
J Am Coll Clin Pharm
. 2024 Nov;
7(6):581-588.
PMID: 39582510
Pharmacogenomics is a growing area of medicine, and pharmacists across clinical practice settings have the opportunity to individualize medication selection and dosing using genetic data. However, many practicing pharmacists may...
3.
Nelson R, Seligson N, Bottiglieri S, Carballido E, Cueto A, Imanirad I, et al.
Cancers (Basel)
. 2024 Nov;
16(21).
PMID: 39518158
In the original publication [...].
4.
Cavallari L, Hicks J, Patel J, Elchynski A, Smith D, Bargal S, et al.
Pharmacogenet Genomics
. 2024 Nov;
35(1):1-11.
PMID: 39485373
Pharmacogenetics promises to optimize treatment-related outcomes by informing optimal drug selection and dosing based on an individual's genotype in conjunction with other important clinical factors. Despite significant evidence of genetic...
5.
Tracksdorf T, Smith D, Pearse S, Cicali E, Aquilante C, Scott S, et al.
Support Care Cancer
. 2024 Jul;
32(8):497.
PMID: 38980476
Purpose: Patients with dihydropyrimidine dehydrogenase (DPD) deficiency are at high risk for severe and fatal toxicity from fluoropyrimidine (FP) chemotherapy. Pre-treatment DPYD testing is standard of care in many countries,...
6.
Alontaga A, Cano P, Ozakinci H, Puskas J, Stewart P, Welsh E, et al.
J Mol Diagn
. 2024 May;
26(8):685-699.
PMID: 38777037
This study describes the validation of a clinical RNA expression panel with evaluation of concordance between gene copy gain by a next-generation sequencing (NGS) assay and high gene expression by...
7.
Hayes T, Aquilanti E, Persky N, Yang X, Kim E, Brenan L, et al.
Nat Commun
. 2024 Apr;
15(1):3273.
PMID: 38627431
No abstract available.
8.
Hayes T, Aquilanti E, Persky N, Yang X, Kim E, Brenan L, et al.
Nat Commun
. 2024 Mar;
15(1):2742.
PMID: 38548752
The epidermal growth factor receptor, EGFR, is frequently activated in lung cancer and glioblastoma by genomic alterations including missense mutations. The different mutation spectra in these diseases are reflected in...
9.
Brock P, Liynarachchi S, Nieminen T, Chan C, Kohlmann W, Stout L, et al.
Thyroid
. 2024 Jan;
34(4):477-483.
PMID: 38279823
Germline pathogenic variants in are associated with a moderate increase in the lifetime risk for breast cancer. Increased risk for other cancers, including non-medullary thyroid cancer (NMTC), has also been...
10.
Seligson N, Kolesar J, Alam B, Baker L, Lamba J, Fridley B, et al.
Pharmacogenomics
. 2023 Sep;
24(13):731-738.
PMID: 37702060
Precision medicine has revolutionized clinical care for patients with cancer through the development of targeted therapy, identification of inherited cancer predisposition syndromes and the use of pharmacogenetics to optimize pharmacotherapy...