J K Killian
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Explore the profile of J K Killian including associated specialties, affiliations and a list of published articles.
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12
Citations
431
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Recent Articles
1.
Voortman J, Harada T, Chang R, Killian J, Suuriniemi M, Smith W, et al.
Curr Pharm Des
. 2012 Sep;
19(5):833-40.
PMID: 22973954
Background: We evaluated the mutation status of c-Met in small cell lung cancer (SCLC) and neuroendocrine tumors (NET), for which relatively limited therapeutic targets have been explored. Materials And Methods:...
2.
Liu F, Killian J, Yang M, Walker R, Hong J, Zhang M, et al.
Oncogene
. 2010 May;
29(25):3650-64.
PMID: 20440268
Limited information is available regarding epigenomic events mediating initiation and progression of tobacco-induced lung cancers. In this study, we established an in vitro system to examine epigenomic effects of cigarette...
3.
Killian J, Nolan C, Wylie A, Li T, Vu T, Hoffman A, et al.
Hum Mol Genet
. 2001 Sep;
10(17):1721-8.
PMID: 11532981
M6P/IGF2R imprinting first appeared approximately 150 million years ago following the divergence of prototherian from therian mammals. Although M6P/IGF2R is clearly imprinted in opossums and rodents, its imprint status in...
4.
Killian J, Nolan C, Stewart N, Munday B, Andersen N, Nicol S, et al.
J Exp Zool
. 2001 Aug;
291(2):205-12.
PMID: 11479919
IGF2 (insulin-like growth factor 2) and M6P/IGF2R (mannose 6-phosphate/insulin-like growth factor 2 receptor) are imprinted in marsupials and eutherians but not in birds. These results along with the absence of...
5.
Nolan C, Killian J, Petitte J, Jirtle R
Dev Genes Evol
. 2001 Jul;
211(4):179-83.
PMID: 11455432
Genomic imprinting is a method of gene regulation whereby a gene is expressed in a parent-of-origin-dependent fashion; however, it is hypothesized that imprinting should not occur in oviparous taxa such...
6.
Killian J, Oka Y, Jang H, Fu X, Waterland R, Sohda T, et al.
Hum Mutat
. 2001 Jul;
18(1):25-31.
PMID: 11438990
M6P/IGF2R encodes a multifunctional protein involved in lysosomal enzyme trafficking, fetal organogenesis, tumor suppression, and cytotoxic T cell-induced apoptosis. M6P/IGF2R is imprinted and expressed only from the maternally inherited allele...
7.
Killian J, Buckley T, Stewart N, Munday B, Jirtle R
Mamm Genome
. 2001 Jun;
12(7):513-7.
PMID: 11420613
The three living monophyletic divisions of Class Mammalia are the Prototheria (monotremes), Metatheria (marsupials), and Eutheria ('placental' mammals). Determining the sister relationships among these three groups is the most fundamental...
8.
Killian J, Byrd J, Jirtle J, Munday B, Stoskopf M, MacDonald R, et al.
Mol Cell
. 2000 Jul;
5(4):707-16.
PMID: 10882106
Imprinted gene identification in animals has been limited to eutherian mammals, suggesting a significant role for intrauterine fetal development in the evolution of imprinting. We report herein that M6P/IGF2R is...
9.
Kong F, Anscher M, Washington M, Killian J, Jirtle R
Oncogene
. 2000 Mar;
19(12):1572-8.
PMID: 10734317
In addition to the intracellular sorting of lysosomal enzymes, the mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R) plays a critical role in regulating the bioavailability of extracellular proteolytic enzymes and...
10.
Hong J, Zang Y, Tejada-Simon M, Kozovska M, Li S, Singh R, et al.
J Immunol
. 1999 Sep;
163(6):3530-8.
PMID: 10477628
T cell responses to the immunodominant peptide (residues 83-99) of myelin basic protein are potentially associated with multiple sclerosis (MS). This study was undertaken to examine whether a common sequence...