J J van Lier
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Explore the profile of J J van Lier including associated specialties, affiliations and a list of published articles.
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14
Citations
94
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Recent Articles
1.
Roffel A, van Marle S, van Lier J, Hartstra J, van Hoogdalem E
J Labelled Comp Radiopharm
. 2016 Dec;
59(14):619-626.
PMID: 28000265
There has been increased interest in conducting human absorption, distribution, metabolism, and excretion (ADME) studies with low doses (up to 0.1 MBq) as opposed to regular doses (1.85-3.7 MBq) of...
2.
Verhoeven C, Gloudemans R, Peeters P, van Lier J, Verheggen F, Groothuis G, et al.
J Steroid Biochem Mol Biol
. 2001 Dec;
78(5):471-80.
PMID: 11738557
The metabolism of desogestrel (13-ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol), a progestagen used in oral contraceptives and hormone replacement therapy, was studied in vivo after a single oral administration of 150 microg [14C]-labeled desogestrel and...
3.
Stangier J, Su C, van Heiningen P, Meinicke T, van Lier J, de Bruin H, et al.
J Cardiovasc Pharmacol
. 2001 Oct;
38(5):672-85.
PMID: 11602814
Telmisartan is a new angiotensin receptor antagonist possessing potent, selective, and insurmountable inhibitory activity specific to the angiotensin II type 1 (AT 1 ) receptor. The current study was performed...
4.
Barrett J, Hainer J, Kornhauser D, Gaskill J, Hua T, Sprogel P, et al.
Thromb Res
. 2001 Mar;
101(4):243-54.
PMID: 11248285
Tinzaparin, a sodium salt of a low-molecular-weight heparin (LMWH) produced via heparinase digestion, is used for the treatment of deep vein thrombosis (DVT) and pulmonary embolism in conjunction with warfarin...
5.
The effect of telmisartan on the steady-state pharmacokinetics of digoxin in healthy male volunteers
Stangier J, Su C, Hendriks M, van Lier J, Sollie F, Oosterhuis B, et al.
J Clin Pharmacol
. 2001 Feb;
40(12 Pt 1):1373-9.
PMID: 11185636
A multiple-dose, open-label, two-period, crossover randomized study was conducted in 12 healthy male volunteers to investigate the effect of multiple-dose telmisartan on the steady-state pharmacokinetics of digoxin. On day 1...
6.
Stangier J, Su C, Hendriks M, van Lier J, Sollie F, Oosterhuis B, et al.
J Clin Pharmacol
. 2001 Feb;
40(12 Pt 1):1331-7.
PMID: 11185631
The effects of multiple-dose telmisartan on the steady-state pharmacodynamics and pharmacokinetics of warfarin were assessed in 12 healthy young males in an open-label, single-period study conducted over 30 days. Subjects...
7.
van Heiningen P, Hatorp V, Kramer Nielsen K, Hansen K, van Lier J, De Merbel N, et al.
Eur J Clin Pharmacol
. 1999 Sep;
55(7):521-5.
PMID: 10501822
Objective: The present study was designed to assess the disposition of (14)C-repaglinide in whole blood, plasma, urine and faeces, and to measure the total recovery of drug-related material in urine...
8.
Seaber E, Peck R, Smith D, Allanson J, Hefting N, van Lier J, et al.
Br J Clin Pharmacol
. 1998 Dec;
46(5):433-9.
PMID: 9833595
Aims: Zolmitriptan (Zomig (formerly 311C90)) is a novel 5-HT1B/1D receptor agonist developed for the acute oral treatment of migraine. A highly sensitive LCMS-MS assay has been developed which allows quantification...
9.
Peeters P, van Lier J, Van De Merbel N, Oosterhuis B, Wieling J, Jonkman J, et al.
Eur J Drug Metab Pharmacokinet
. 1998 Jun;
23(1):45-53.
PMID: 9625272
Losigamone ((+/-)-(R*,S*)-5-(2-chlorophenylhydroxymethyl)-4-methoxy-2 (5H)-furanone; AO-33) is a new potential antiepileptic drug undergoing clinical development. In a crossover study, 200 mg [14C]-labelled Losigamone, as well as 100 mg of each of the...
10.
Jonkman J, van Lier J, van Heiningen P, Lins R, Sennewald R, Hogemann A
J Hum Hypertens
. 1997 Oct;
11 Suppl 2:S31-5.
PMID: 9331003
The aim of this series of studies was to determine the potential for pharmacokinetic interaction between candesartan (administered orally as the prodrug candesartan cilexetil) and hydrochlorothiazide (HCTZ), nifedipine, glibenclamide, warfarin,...