J Heasman
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Explore the profile of J Heasman including associated specialties, affiliations and a list of published articles.
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74
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1717
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Recent Articles
1.
Eastwood S, Tillin T, Mayet J, Shibata D, Wright A, Heasman J, et al.
Diabet Med
. 2015 Aug;
33(3):340-7.
PMID: 26314829
Aims: We contrasted impaired glucose regulation (prediabetes) prevalence, defined according to oral glucose tolerance test or HbA1c values, and studied cross-sectional associations between prediabetes and subclinical/clinical cardiovascular disease (CVD) in...
2.
Wylie C, Heasman J
Trends Cell Biol
. 2007 Aug;
7(11):459-62.
PMID: 17709007
In Xenopus, mRNAs synthesized during oocyte differentiation are inherited by the egg and direct all protein synthesis until the late-blastula stage. This provides an opportunity to study the roles of...
3.
Cha J, Birsoy B, Kofron M, Mahoney E, Lang S, Wylie C, et al.
Dev Dyn
. 2007 Aug;
236(10):2731-41.
PMID: 17705306
FoxC1 is an important transcription factor in vertebrate development since its mutation in humans results in Axenfeld-Rieger syndrome. In the mouse, disturbance of its function causes congenital hydrocephalus and abnormalities...
4.
Heasman J, Wessely O, Langland R, Craig E, Kessler D
Dev Biol
. 2002 Jan;
240(2):377-86.
PMID: 11784070
VegT is an essential maternal regulator of germ layer specification in Xenopus. The localization of VegT mRNA to the vegetal cortex of the oocyte during oogenesis ensures its inheritance by...
5.
Lee M, Heasman J, Whitman M
Development
. 2001 Sep;
128(15):2939-52.
PMID: 11532917
Signaling by activin-like ligands is important for induction and patterning of mesoderm and endoderm. We have used an antibody that specifically recognizes the phosphorylated and activated form of Smad2, an...
6.
Kofron M, Klein P, Zhang F, Houston D, Schaible K, Wylie C, et al.
Dev Biol
. 2001 Aug;
237(1):183-201.
PMID: 11518515
Regulation of the stability of beta catenin protein is a critical role of Wnt signaling cascades. In early Xenopus development, dorsal axis specification depends on regulation of beta catenin by...
7.
Anderson O, Heasman J, Wylie C
Int Rev Cytol
. 2000 Dec;
203:215-30.
PMID: 11131517
Germ cells represent the genetic and cellular link between generations, as well as the transmitters of inherited diseases. Despite their central importance, not much is known about the molecular mechanisms...
8.
Xanthos J, Kofron M, Wylie C, Heasman J
Development
. 2000 Dec;
128(2):167-80.
PMID: 11124113
During cleavage stages, maternal VegT mRNA and protein are localized to the Xenopus embryo's vegetal region from which the endoderm will arise and where several zygotic gene transcripts will be...
9.
Heasman J, Kofron M, Wylie C
Dev Biol
. 2000 Jul;
222(1):124-34.
PMID: 10885751
Xenopus embryos develop dorsal/ventral and anterior/posterior axes as a result of the activity of a maternal Xwnt pathway, in which beta-catenin is an essential component, acting as a transactivator of...
10.
Sumanas S, Strege P, Heasman J, Ekker S
Development
. 2000 Apr;
127(9):1981-90.
PMID: 10751186
We have isolated one member of the frizzled family of wnt receptors from Xenopus (Xfz7) to study the role of cell-cell communication in the establishment of the vertebrate axis. We...