J H Hegemann
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Explore the profile of J H Hegemann including associated specialties, affiliations and a list of published articles.
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43
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4455
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Recent Articles
1.
Fiedler T, Karpova T, Fleig U, Young M, Cooper J, Hegemann J
Mol Genet Genomics
. 2002 Oct;
268(2):190-205.
PMID: 12395193
The CGP1 gene was identified in a screen for mutations that were synthetic lethal in combination with a deletion of the gene (CPF1) for centromere and promoter factor 1. Cells...
2.
Gueldener U, Heinisch J, Koehler G, Voss D, Hegemann J
Nucleic Acids Res
. 2002 Mar;
30(6):e23.
PMID: 11884642
Heterologous markers are important tools required for the molecular dissection of gene function in many organisms, including Saccharomyces cerevisiae. Moreover, the presence of gene families and isoenzymes often makes it...
3.
Wuppermann F, Hegemann J, Jantos C
J Infect Dis
. 2001 Jun;
184(2):181-7.
PMID: 11424015
Chlamydia pneumoniae is an important human intracellular pathogen; however, the pathogenesis of C. pneumoniae infection is poorly understood, and the bacterial adherence mechanism to host cells is unknown. This study...
4.
Ramos C, Guldener U, Klein S, Hegemann J, Gonzalez S, Rodriguez-Medina J
IUBMB Life
. 2001 May;
50(6):371-7.
PMID: 11327310
Our results demonstrate that open reading frame (ORF) YHR076w on chromosome VIII of Saccharomyces cerevisiae that was previously described as a hypothetical gene is expressed. This ORF is transcribed as...
5.
Jahn H, Krull M, Wuppermann F, Klucken A, Rosseau S, Seybold J, et al.
J Infect Dis
. 2000 Nov;
182(6):1678-87.
PMID: 11069240
The activation of primary human airway epithelial cells (HAECs) and of the bronchial epithelial cell line BEAS-2B by Chlamydia pneumoniae, an important respiratory pathogen, was characterized. A time-dependent enhanced release...
6.
Jantos C, Krombach C, Wuppermann F, Gardemann A, Bepler S, Asslan H, et al.
J Infect Dis
. 2000 May;
181(5):1700-5.
PMID: 10823771
Serum specimens from 752 individuals undergoing coronary arteriography were examined for antibodies to Chlamydia pneumoniae. Patients with coronary artery disease (CAD) were more likely to have IgG antibodies to C....
7.
Entian K, Schuster T, Hegemann J, Becher D, Feldmann H, Guldener U, et al.
Mol Gen Genet
. 2000 Jan;
262(4-5):683-702.
PMID: 10628851
In a systematic approach to the study of Saccharomyces cerevisiae genes of unknown function, 150 deletion mutants were constructed (1 double, 149 single mutants) and phenotypically analysed. Twenty percent of...
8.
Niedenthal R, Riles L, Guldener U, Klein S, Johnston M, Hegemann J
Yeast
. 1999 Dec;
15(16):1775-96.
PMID: 10590466
To begin genome-wide functional analysis, we analysed the consequences of deleting each of the 265 genes of chromosome VIII of Saccharomyces cerevisiae. For 33% of the deletion strains a growth...
9.
Winzeler E, Shoemaker D, Astromoff A, Liang H, Anderson K, Andre B, et al.
Science
. 1999 Aug;
285(5429):901-6.
PMID: 10436161
The functions of many open reading frames (ORFs) identified in genome-sequencing projects are unknown. New, whole-genome approaches are required to systematically determine their function. A total of 6925 Saccharomyces cerevisiae...
10.
Hegemann J, Klein S, Heck S, Guldener U, Niedenthal R, Fleig U
Yeast
. 1999 Jul;
15(10B):1009-19.
PMID: 10407280
We have developed a simple, fast and reliable method for the analysis of genetic stability in budding yeast strains. The assay relies on our previous finding that cells expressing the...