J H Darbyshire
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Explore the profile of J H Darbyshire including associated specialties, affiliations and a list of published articles.
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102
Citations
1196
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Recent Articles
1.
Mead S, Ranopa M, Gopalakrishnan G, Thompson A, Rudge P, Wroe S, et al.
Neurology
. 2011 Oct;
77(18):1674-83.
PMID: 22013183
Objectives: Human prion diseases are heterogeneous but invariably fatal neurodegenerative disorders with no known effective therapy. PRION-1, the largest clinical trial in prion disease to date, showed no effect of...
2.
Walker A, Ford D, Gilks C, Munderi P, Ssali F, Reid A, et al.
Lancet
. 2010 Mar;
375(9722):1278-86.
PMID: 20347483
Background: Co-trimoxazole prophylaxis can reduce mortality from untreated HIV infection in Africa; whether benefits occur alongside combination antiretroviral therapy (ART) is unclear. We estimated the effect of prophylaxis after ART...
3.
Munderi P, Walker A, Kityo C, Babiker A, Ssali F, Reid A, et al.
HIV Med
. 2010 Feb;
11(5):334-44.
PMID: 20136661
Background: Triple nucleoside reverse transcriptase inhibitor regimens have advantages as first-line antiretroviral therapy (ART), avoiding hepatotoxicity and interactions with anti-tuberculosis therapy, and sparing two drug classes for second-line ART. Concerns...
4.
Babiker A, Gilks C, Munderi P, Kabuye G, Kasirye R, Zalwango E, et al.
Lancet
. 2009 Dec;
375(9709):123-31.
PMID: 20004464
Background: HIV antiretroviral therapy (ART) is often managed without routine laboratory monitoring in Africa; however, the effect of this approach is unknown. This trial investigated whether routine toxicity and efficacy...
5.
6.
Matthews D, Kennedy E, Darbyshire J, Johnston D
Diabet Med
. 2007 Jan;
24(1):7-9.
PMID: 17227318
The Department of Health has funded a national diabetes network to support clinical research. The network will facilitate recruitment into clinical trials and has been widely welcomed by clinicians. However,...
7.
Yeni P, Cooper D, Aboulker J, Babiker A, Carey D, Darbyshire J, et al.
Lancet
. 2006 Jul;
368(9532):287-98.
PMID: 16860698
Background: Antiretroviral therapy has greatly reduced HIV mortality and morbidity. However, the best sequence of regimens and implications of initial regimen for long-term therapeutic success are not well defined. Methods:...
8.
Dunn D, Green H, Loveday C, Rinehart A, Pillay D, Fisher M, et al.
J Acquir Immune Defic Syndr
. 2005 Mar;
38(5):553-9.
PMID: 15793365
Objectives: To assess the clinical utility of phenotypic resistance testing in addition to genotypic resistance testing among HIV-1-infected patients experiencing virologic failure and with limited therapeutic options. Design: Multicenter randomized...
9.
Grant A, Altman D, Babiker A, Campbell M, Clemens F, Darbyshire J, et al.
Health Technol Assess
. 2005 Mar;
9(7):1-238, iii-iv.
PMID: 15763038
Objectives: To address issues about data monitoring committees (DMCs) for randomised controlled trials (RCTs). Data Sources: Electronic databases. Handsearching of selected books. Personal contacts with experts in the field. Review...
10.
Touloumi G, Babiker A, Kenward M, Pocock S, Darbyshire J
Stat Med
. 2003 Oct;
22(20):3161-75.
PMID: 14518021
Several methods for the estimation and comparison of rates of change in longitudinal studies with staggered entry and informative drop-outs have been recently proposed. For multivariate normal linear models, REML...