J Clos
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Explore the profile of J Clos including associated specialties, affiliations and a list of published articles.
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77
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1380
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Recent Articles
1.
Dumetz F, Cuypers B, Imamura H, Zander D, DHaenens E, Maes I, et al.
mSphere
. 2018 Apr;
3(2).
PMID: 29669889
Antimonials (Sb) were used for decades for chemotherapy of visceral leishmaniasis (VL). Now abandoned in the Indian subcontinent (ISC) because of resistance, this drug offers a unique model for understanding...
2.
Normand G, Clos J, Vincendon G, Gombos G
Int J Dev Neurosci
. 2014 May;
3(3):245-56.
PMID: 24874752
Modifications of glycosaminoglycans were studied during rat cerebellum ontogenesis. Levels of both hyaluronic acid and sulphated glycosaminoglycans increase during development but not at the same rate as cerebellar size or...
3.
Ghandour M, Langley O, Clos J
Int J Dev Neurosci
. 2014 May;
1(6):411-25.
PMID: 24873695
Immunocytochemical methods have in recent years played a more important role in investigations of the development and function of glial cells in the nervous system because of their potential to...
4.
Hombach A, Clos J
Parasitology
. 2014 Apr;
141(9):1156-66.
PMID: 24703183
SUMMARY Hsp90 (a.k.a. Hsp83) plays a significant role in the life cycle control of the protozoan parasite Leishmania donovani. Rather than protecting Leishmania spp. against adverse and stressful environs, Hsp90...
5.
Clos J, Brandau S, Hoyer C
Protist
. 2012 Dec;
149(2):167-72.
PMID: 23196166
The cellular heat shock response in kinetoplastid protozoa is regulated exclusively at a post-transcriptional level. The heat-inducibility of heat shock protein synthesis is retained under actinomycin C(1) which indicates an...
6.
Silva Junior F, Veyl F, Clos J, Giovanni de Simone S
Mem Inst Oswaldo Cruz
. 2002 Jun;
97(3):335-41.
PMID: 12048561
The great expansion in the number of genome sequencing projects has revealed the importance of computational methods to speed up the characterization of unknown genes. These studies have been improved...
7.
Clos J, Klaholz L, Kroemer M, Krobitsch S, Lindquist S
Med Microbiol Immunol
. 2002 Jan;
190(1-2):47-50.
PMID: 11770109
HSP100 protein in Leishmania spp. plays an important role for the survival and integrity of intracellular amastigotes. The A2 proteins of L. donovani are functionally linked to HSP100. There is...
8.
Hoyer C, Mellenthin K, Schilhabel M, Platzer M, Clos J
Med Microbiol Immunol
. 2002 Jan;
190(1-2):43-6.
PMID: 11770108
We have employed a genetic complementation screening to identify genetic markers of heat stress tolerance and visceralisation of Leishmania infection. Leishmania major, which has a low thermotolerance and which causes...
9.
Wiesgigl M, Clos J
Med Microbiol Immunol
. 2002 Jan;
190(1-2):27-31.
PMID: 11770104
The 90-kDa heat shock protein (Hsp90) of Leishmania donovani is a highly abundant cytoplasmic protein and is involved in a variety of cellular processes. Pharmacological deactivation of Hsp90 leads to...
10.
Wiesgigl M, Clos J
Mol Biol Cell
. 2001 Nov;
12(11):3307-16.
PMID: 11694568
The differentiation of Leishmania parasites from the insect stage, the promastigote, toward the pathogenic mammalian stage, the amastigote, is triggered primarily by the rise in ambient temperature encountered during the...