J C Lacey Jr
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Explore the profile of J C Lacey Jr including associated specialties, affiliations and a list of published articles.
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44
Citations
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Recent Articles
1.
Wickramasinghe N, Lacey Jr J
Mol Cell Biochem
. 1994 Oct;
139(2):117-21.
PMID: 7862102
Recent reports suggest that the ribosome retains considerable peptidyl transferase activity even when much of the protein of the ribosome is removed and further suggests that rRNA may be the...
2.
Lacey Jr J, Wickramasinghe N, Cook G, Anderson G
J Mol Evol
. 1993 Sep;
37(3):233-9.
PMID: 7693954
Data from the literature and new data presented here suggest that the genetic system (coding and protein synthesis) is based on relationships of character and structure between amino acids and...
3.
Wickramasinghe N, Lacey Jr J
Chirality
. 1993 Jan;
5:150-3.
PMID: 11540505
Studies of the properties of aminoacyl derivatives of 5'-AMP are aimed at understanding the origin of the process of protein synthesis. Aminoacyl (2',3') esters of 5'-AMP can serve as models...
4.
Lacey Jr J, Wickramasinghe N, Sabatini R
Experientia
. 1992 Apr;
48(4):379-83.
PMID: 1582495
We have studied the chemistry of aminoacyl AMP to model reactions at the 3' terminus of aminoacyl tRNA for the purpose of understanding the origin of protein synthesis. The present...
5.
Lacey Jr J, Wickramasinghe N, Cook G
Orig Life Evol Biosph
. 1992 Jan;
22(5):243-75.
PMID: 1454353
This article is an update of our earlier review (Lacey and Mullins, 1983) in this journal on the origin of the genetic code and the process of protein synthesis. It...
6.
Wickramasinghe N, Lacey Jr J
Bioorg Chem
. 1992 Jan;
20:265-8.
PMID: 11540890
We recently reported that esterification of 5'-AMP with N-acetyl amino acids proceeds with a preference for D-amino acids, and the D/L ratio in products declines as the hydrophobicity of the...
7.
Wickramasinghe N, Lacey Jr J
Orig Life Evol Biosph
. 1992 Jan;
22:361-8.
PMID: 11537548
Procedures for the formation of aminoacyl esters of monoribonucleotides with aminoacyl imidazolides were first reported by Gottikh et al. and summarized in 1970. This reaction has been widely used by...
8.
Wickramasinghe N, Staves M, Lacey Jr J
Biochemistry
. 1991 Mar;
30(11):2768-72.
PMID: 2007115
Biological systems synthesize proteins with an almost exclusive use of L-amino acids and virtually none of the D isomer. There has been no satisfactory explanation for the origin of this...
9.
Lacey Jr J, Thomas R, Wickaramasinghe N, Watkins C
J Mol Evol
. 1990 Oct;
31(4):251-6.
PMID: 2175365
We describe experiments here which show that chemical esterification of 5'-adenylic acid (5'-AMP) with N-acetyl D- or L-phenylalanine (Ac-D- or Ac-L-Phe) imidazolide occurs principally, if not exclusively, at the 2'...
10.
Lacey Jr J, Staves M, Thomas R
J Mol Evol
. 1990 Sep;
31(3):244-8.
PMID: 1698989
This minireview is a summary of the basic concepts and pieces of experimental evidence supporting a hypothesis that suggests a mechanism whereby purine monoribonucleotides having D-ribose may be able to...