J C Hozier
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Explore the profile of J C Hozier including associated specialties, affiliations and a list of published articles.
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37
Citations
185
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Recent Articles
11.
Liechty M, Hall B, Scalzi J, Davis L, Caspary W, Hozier J
Mamm Genome
. 1995 Sep;
6(9):592-4.
PMID: 8535064
Using degenerate primer amplification of chromosomes microdissected from banded cytogenetic preparations, we constructed both whole chromosome painting probes for mouse Chromosomes (Chrs) 1, 2, 3, and 11 and a centromere...
12.
Liechty M, Hassanpour Z, Hozier J, CLIVE D
Mutagenesis
. 1994 Sep;
9(5):423-7.
PMID: 7837976
The mouse lymphoma (L5178Y tk+/- 3.7.2C) in vitro mutagenesis assay can measure the genotoxic effects of a wide variety of chemical agents by inactivation of a single functional thymidine kinase...
13.
Davis L, Caspary W, Sakallah S, Maronpot R, Wiseman R, Barrett J, et al.
Carcinogenesis
. 1994 Aug;
15(8):1637-45.
PMID: 8055644
The B6C3F1 mouse is used worldwide to gauge the carcinogenic hazard posed by chemicals to humans. An assessment of the ability of this rodent model to predict human neoplasia requires...
14.
Liechty M, Rauchfuss H, Lugo M, Hozier J
Mutat Res
. 1993 Apr;
286(2):299-307.
PMID: 7681542
The mouse-lymphoma mutagenesis assay detects forward mutations at the heterozygous thymidine kinase (tk-1) locus in L5178Y tk+/- 3.7.2C cells. This assay of genotoxicity is widely used to quantitate the mutagenic...
15.
16.
CLIVE D, Corey L, Reichman R, Davis L, Hozier J
J Infect Dis
. 1991 Oct;
164(4):753-7.
PMID: 1894936
The antiherpes drug acyclovir breaks chromosomes in vitro at millimolar concentrations and at highly toxic doses in rodents but does not induce single-gene mutations. Recurrent genital herpes patients were examined...
17.
Moore M, Parker L, Doerr C, Hozier J
Mutat Res
. 1991 Aug;
253(1):63-71.
PMID: 1651446
2-Amino-6-N-hydroxyadenine (AHA) treated L5178Y/TK (+/-)-3.7.2C mouse lymphoma cells were evaluated for mutations at the tk, hgprt, and Na+/K+ ATPase loci, as well as for gross chromosome aberrations and induction of...
18.
Hozier J
Environ Mol Mutagen
. 1991 Jan;
18(4):255-8.
PMID: 1748087
Molecular genetic techniques have been used effectively to study the DNA lesions, many of which are large and complex, that are responsible for human genetic disease. In this workshop we...
19.
Molecular dissection of mutations at the heterozygous thymidine kinase locus in mouse lymphoma cells
Applegate M, Moore M, Broder C, Burrell A, Juhn G, Kasweck K, et al.
Proc Natl Acad Sci U S A
. 1990 Jan;
87(1):51-5.
PMID: 1967496
The mouse lymphoma L5178Y TK+/- 3.7.2C cell line allows quantitation of induced TK(+/-)----TK-/- mutations at the heterozygous thymidine kinase (Tk) locus. TK-/- mutant colonies show a bimodal size distribution, reflecting...
20.
Hozier J, Sawyer J, Moore M
Mutat Res
. 1989 Oct;
214(2):195-9.
PMID: 2797025
Since the finding that the mouse lymphoma L5178Y TK+/- ----TK-/- forward mutational assay system can detect and distinguish a range of genetic lesions, including large chromosomal aberrations and smaller, perhaps...